N⁴-benzoyl-1-<2-deoxy-2-methylidene-3,5-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl>cytosine

Base Information

• Chemical Name: N⁴-benzoyl-1-<2-deoxy-2-methylidene-3,5-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl>cytosine
• CAS No.: 119411-04-0
• Molecular Formula: C₂₉H₄₅N₃O₅Si₂
• Molecular Weight: 571.864

Synonyms:N⁴-benzoyl-1-<2-deoxy-2-methylidene-3,5-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl>cytosine

Chemical Property of N⁴-benzoyl-1-<2-deoxy-2-methylidene-3,5-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl>cytosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁴-benzoyl-1-<2-deoxy-2-methylidene-3,5-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl>cytosine

There total 3 articles about N⁴-benzoyl-1-<2-deoxy-2-methylidene-3,5-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl>cytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

[(2R,3S,3aR,9aR)-2-(4-Benzylamino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-ylmethyl]-triphenyl-phosphonium; bromide (130954-02-8) → N4-benzoyl-1-<2-deoxy-2-methylidene-3,5-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl>cytosine (119411-04-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran; for 2h; Ambient temperature;

DOI:10.1021/jm00106a049

Reference yield:

Methyltriphenylphosphonium bromide (1779-49-3) + N4-benzoyl-1-<3,5-O-(tetraisopropyldidiloxane-1,3-diyl)-β-D-erythro-pentofuran-2-ulosyl>cytosine (119411-03-9) → N4-benzoyl-1-<2-deoxy-2-methylidene-3,5-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl>cytosine (119411-04-0) + [(2R,3S,3aR,9aR)-2-(4-Benzylamino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-ylmethyl]-triphenyl-phosphonium; bromide (130954-02-8)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction. Yields of byproduct given; 1.) hexane, THF, -20 deg C, 1 h, 2.) RT, 2 h;

DOI:10.1021/jm00106a049

Reference yield:

Methyltriphenylphosphonium bromide (1779-49-3) + N4-benzoyl-1-<3,5-O-(tetraisopropyldidiloxane-1,3-diyl)-β-D-erythro-pentofuran-2-ulosyl>cytosine (119411-03-9) → N4-benzoyl-1-<2-deoxy-2-methylidene-3,5-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl>cytosine (119411-04-0)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1021/jm00106a049

upstream raw materials:

Methyltriphenylphosphonium bromide

N⁴-benzoyl-1-<3,5-O-(tetraisopropyldidiloxane-1,3-diyl)-β-D-erythro-pentofuran-2-ulosyl>cytosine

[(2R,3S,3aR,9aR)-2-(4-Benzylamino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-ylmethyl]-triphenyl-phosphonium; bromide

Downstream raw materials:

N⁴-benzoyl-2'-deoxy-2'-methylidenecytidine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 119411-04-0 N⁴-benzoyl-1-<2-deoxy-2-methylidene-3,5-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl>cytosine

Send

Send

Metric Ton KG G Pound L ML

Send

Send