(S)-5-Benzyloxy-2-{(1S,4S,5S)-4-(tert-butyl-diphenyl-silanyloxymethyl)-4-methyl-5-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-cyclopent-2-enyl}-pentan-1-ol

Base Information

• Chemical Name: (S)-5-Benzyloxy-2-{(1S,4S,5S)-4-(tert-butyl-diphenyl-silanyloxymethyl)-4-methyl-5-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-cyclopent-2-enyl}-pentan-1-ol
• CAS No.: 119594-24-0
• Molecular Formula: C₄₂H₅₈O₅Si
• Molecular Weight: 671.005
• Mol file: 119594-24-0.mol

Synonyms:(S)-5-Benzyloxy-2-{(1S,4S,5S)-4-(tert-butyl-diphenyl-silanyloxymethyl)-4-methyl-5-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-cyclopent-2-enyl}-pentan-1-ol

Chemical Property of (S)-5-Benzyloxy-2-{(1S,4S,5S)-4-(tert-butyl-diphenyl-silanyloxymethyl)-4-methyl-5-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-cyclopent-2-enyl}-pentan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-5-Benzyloxy-2-{(1S,4S,5S)-4-(tert-butyl-diphenyl-silanyloxymethyl)-4-methyl-5-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-cyclopent-2-enyl}-pentan-1-ol

There total 2 articles about (S)-5-Benzyloxy-2-{(1S,4S,5S)-4-(tert-butyl-diphenyl-silanyloxymethyl)-4-methyl-5-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-cyclopent-2-enyl}-pentan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-5-Benzyloxy-2-{(1S,4S,5S)-4-(tert-butyl-diphenyl-silanyloxymethyl)-4-methyl-5-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-cyclopent-2-enyl}-pentanoic acid methyl ester (119594-23-9) → (S)-5-Benzyloxy-2-{(1S,4S,5S)-4-(tert-butyl-diphenyl-silanyloxymethyl)-4-methyl-5-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-cyclopent-2-enyl}-pentan-1-ol (119594-24-0)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃;

DOI:10.1021/ja00189a069

Reference yield:

C48H70O6Si2 (119594-22-8,119678-58-9) → (S)-5-Benzyloxy-2-{(1S,4S,5S)-4-(tert-butyl-diphenyl-silanyloxymethyl)-4-methyl-5-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-cyclopent-2-enyl}-pentan-1-ol (119594-24-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1M HCl / methanol; diethyl ether / Ambient temperature

2: diethyl ether / 0 °C

3: LiAlH₄ / diethyl ether / 0 °C

With hydrogenchloride; lithium aluminium tetrahydride; In methanol; diethyl ether;

DOI:10.1021/ja00189a069

Reference yield:

(S)-5-Benzyloxy-2-{(1S,4S,5S)-4-(tert-butyl-diphenyl-silanyloxymethyl)-4-methyl-5-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-cyclopent-2-enyl}-pentan-1-ol (119594-24-0) → 2,2-Dimethyl-propionic acid (S)-4-{(1R,2S,3S)-3-(tert-butyl-diphenyl-silanyloxymethyl)-3-methyl-2-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-cyclopentyl}-pentyl ester (119594-28-4)

Guidance literature:

Multi-step reaction with 5 steps

1: Et₃N / CH₂Cl₂ / 0 °C

2: LiAlH₄ / diethyl ether / Ambient temperature

3: H₂ / PtO₂ / ethyl acetate / 760 Torr / Ambient temperature

4: H₂ / Pd(OH)2 / ethanol / 760 Torr / Ambient temperature

5: pyridine / Ambient temperature

With pyridine; lithium aluminium tetrahydride; hydrogen; triethylamine; platinum(IV) oxide; palladium dihydroxide; In diethyl ether; ethanol; dichloromethane; ethyl acetate;

DOI:10.1021/ja00189a069

upstream raw materials:

(S)-5-Benzyloxy-2-{(1S,4S,5S)-4-(tert-butyl-diphenyl-silanyloxymethyl)-4-methyl-5-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-cyclopent-2-enyl}-pentanoic acid methyl ester

C₄₈H₇₀O₆Si₂

Downstream raw materials:

Methanesulfonic acid (S)-5-benzyloxy-2-{(1S,4S,5S)-4-(tert-butyl-diphenyl-silanyloxymethyl)-4-methyl-5-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-cyclopent-2-enyl}-pentyl ester

Ophiobolin C

(S)-4-{(1R,2S,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-3-methyl-2-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-cyclopentyl}-pentan-1-ol

{(1S,2S,3R)-3-((S)-4-Benzyloxy-1-methyl-butyl)-1-methyl-2-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-cyclopentylmethoxy}-tert-butyl-diphenyl-silane