di-tert-butyl 5-(3-(2-chlorobenzyl)-7-fluoro-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-2-oxo-1H-benzo[d]imidazole-1,3(2H)-dicarboxylate

Base Information

Chemical Name:di-tert-butyl 5-(3-(2-chlorobenzyl)-7-fluoro-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-2-oxo-1H-benzo[d]imidazole-1,3(2H)-dicarboxylate
CAS No.:1276544-63-8
Molecular Formula:C₄₁H₄₀ClFN₄O₇
Molecular Weight:755.243
Hs Code.:

di-tert-butyl 5-(3-(2-chlorobenzyl)-7-fluoro-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-2-oxo-1H-benzo[d]imidazole-1,3(2H)-dicarboxylate

Synonyms:di-tert-butyl 5-(3-(2-chlorobenzyl)-7-fluoro-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-2-oxo-1H-benzo[d]imidazole-1,3(2H)-dicarboxylate

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Chemical Property of di-tert-butyl 5-(3-(2-chlorobenzyl)-7-fluoro-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-2-oxo-1H-benzo[d]imidazole-1,3(2H)-dicarboxylate

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Technology Process of di-tert-butyl 5-(3-(2-chlorobenzyl)-7-fluoro-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-2-oxo-1H-benzo[d]imidazole-1,3(2H)-dicarboxylate

There total 5 articles about di-tert-butyl 5-(3-(2-chlorobenzyl)-7-fluoro-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-2-oxo-1H-benzo[d]imidazole-1,3(2H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1276544-65-0
di-tert-butyl 2-oxo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole-1,3-(2H)-dicarboxylate

: 1276544-64-9
C₂₄H₁₉Cl₂FN₂O₂

: 1276544-63-8
di-tert-butyl 5-(3-(2-chlorobenzyl)-7-fluoro-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-2-oxo-1H-benzo[d]imidazole-1,3(2H)-dicarboxylate

Guidance literature:: With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; isopropyl alcohol; toluene; at 60 ℃; for 6h; Inert atmosphere;

Reference yield:

: 446-08-2
2-amino-5-fluorobenzoic acid

: 1276544-63-8
di-tert-butyl 5-(3-(2-chlorobenzyl)-7-fluoro-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-2-oxo-1H-benzo[d]imidazole-1,3(2H)-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 20 °C

2.1: triethylamine / acetonitrile; water / 20 °C

2.2: Heating

3.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

4.1: trichlorophosphate; N,N-dimethyl-aniline / toluene / 90 °C

5.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / isopropyl alcohol; toluene; water / 6 h / 60 °C / Inert atmosphere

With sodium hydrogencarbonate; potassium carbonate; N,N-dimethyl-aniline; triethylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; acetonitrile;

Reference yield:

: 321-69-7
5-fluoroisatoic anhydride

: 1276544-63-8
di-tert-butyl 5-(3-(2-chlorobenzyl)-7-fluoro-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-2-oxo-1H-benzo[d]imidazole-1,3(2H)-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / acetonitrile; water / 20 °C

1.2: Heating

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: trichlorophosphate; N,N-dimethyl-aniline / toluene / 90 °C

4.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / isopropyl alcohol; toluene; water / 6 h / 60 °C / Inert atmosphere

With sodium hydrogencarbonate; potassium carbonate; N,N-dimethyl-aniline; triethylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; acetonitrile;