Technology Process of C33H30F3N5O4S
There total 7 articles about C33H30F3N5O4S which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
benzyloxyacetic acid;
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine;
In
N,N-dimethyl-formamide;
for 0.5h;
6-[(4-tert-butylphenyl)sulfonyl]-N'-hydroxy-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepine-7-carboximidamide;
In
N,N-dimethyl-formamide;
at 70 ℃;
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
for 1h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: borane-THF / tetrahydrofuran / 0 - 20 °C
2.1: pyridine; dmap / dichloromethane / 12 h / 0 - 20 °C
3.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium(0) / water; N,N-dimethyl-formamide / 0.33 h / 150 °C / Inert atmosphere; Microwave irradiation
4.1: hydroxylamine; potassium carbonate / ethanol; water / 0.33 h / 120 °C / Microwave irradiation
5.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.5 h
5.2: 70 °C
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; pyridine; dmap; tris-(dibenzylideneacetone)dipalladium(0); borane-THF; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydroxylamine; potassium carbonate; triethylamine;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ml200304j
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: pyridine; dmap / dichloromethane / 12 h / 0 - 20 °C
2.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium(0) / water; N,N-dimethyl-formamide / 0.33 h / 150 °C / Inert atmosphere; Microwave irradiation
3.1: hydroxylamine; potassium carbonate / ethanol; water / 0.33 h / 120 °C / Microwave irradiation
4.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.5 h
4.2: 70 °C
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; pyridine; dmap; tris-(dibenzylideneacetone)dipalladium(0); benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydroxylamine; potassium carbonate; triethylamine;
In
ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ml200304j
