Technology Process of 2-(1-(4-methyl-3-(2,2,2-trifluoroethylthio)phenyl)-3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl)pyridine
There total 6 articles about 2-(1-(4-methyl-3-(2,2,2-trifluoroethylthio)phenyl)-3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl)pyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
rongalite; potassium carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 16h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium acetate / ethanol / 2 h / Reflux
2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.5 h / 20 °C
3.1: ammonia / chloroform; water / 1.5 h / 20 °C
4.1: toluene-4-sulfonic acid / toluene / 1 h / Reflux
4.2: 20 h / 20 °C
5.1: chlorosulfonic acid / 3 h / 120 °C / Cooling with ice
6.1: phosphorus; acetic acid / iodine / 1.5 h / 100 °C
7.1: potassium carbonate; rongalite / N,N-dimethyl-formamide / 16 h / 20 °C
With
chlorosulfonic acid; phosphorus; N-Bromosuccinimide; ammonia; sodium acetate; rongalite; potassium carbonate; toluene-4-sulfonic acid; acetic acid;
iodine;
In
ethanol; chloroform; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: toluene-4-sulfonic acid / toluene / 1 h / Reflux
1.2: 20 h / 20 °C
2.1: chlorosulfonic acid / 3 h / 120 °C / Cooling with ice
3.1: phosphorus; acetic acid / iodine / 1.5 h / 100 °C
4.1: potassium carbonate; rongalite / N,N-dimethyl-formamide / 16 h / 20 °C
With
chlorosulfonic acid; phosphorus; rongalite; potassium carbonate; toluene-4-sulfonic acid; acetic acid;
iodine;
In
N,N-dimethyl-formamide; toluene;