2-Cyano-3-(4-fluoro-phenyl)-3-(2-hydroxy-4,4-dimethyl-6-oxo-cyclohex-1-enyl)-thiopropionamide; compound with morpholine

Base Information

• Chemical Name: 2-Cyano-3-(4-fluoro-phenyl)-3-(2-hydroxy-4,4-dimethyl-6-oxo-cyclohex-1-enyl)-thiopropionamide; compound with morpholine
• CAS No.: 131270-65-0
• Molecular Formula: C₄H₉NO*C₁₈H₁₉FN₂O₂S
• Molecular Weight: 433.547
• Mol file: 131270-65-0.mol

Synonyms:2-Cyano-3-(4-fluoro-phenyl)-3-(2-hydroxy-4,4-dimethyl-6-oxo-cyclohex-1-enyl)-thiopropionamide; compound with morpholine

Chemical Property of 2-Cyano-3-(4-fluoro-phenyl)-3-(2-hydroxy-4,4-dimethyl-6-oxo-cyclohex-1-enyl)-thiopropionamide; compound with morpholine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Cyano-3-(4-fluoro-phenyl)-3-(2-hydroxy-4,4-dimethyl-6-oxo-cyclohex-1-enyl)-thiopropionamide; compound with morpholine

There total 2 articles about 2-Cyano-3-(4-fluoro-phenyl)-3-(2-hydroxy-4,4-dimethyl-6-oxo-cyclohex-1-enyl)-thiopropionamide; compound with morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

morpholine (110-91-8,99108-56-2) + 2-cyano-3-(4-fluorophenyl)prop-2-enethioamide (97579-25-4) + dimedone (126-81-8) → 2-Cyano-3-(4-fluoro-phenyl)-3-(2-hydroxy-4,4-dimethyl-6-oxo-cyclohex-1-enyl)-thiopropionamide; compound with morpholine (131270-65-0)

Guidance literature:

In ethanol; at 20 - 25 ℃; for 5h;

Reference yield: 91.0%

morpholine (110-91-8,99108-56-2) + (E)-2-cyano-3-(4-fluorophenyl)prop-2-enethioamide (68029-40-3) + dimedone (126-81-8) → 2-Cyano-3-(4-fluoro-phenyl)-3-(2-hydroxy-4,4-dimethyl-6-oxo-cyclohex-1-enyl)-thiopropionamide; compound with morpholine (131270-65-0)

Guidance literature:

In ethanol; at 25 ℃; for 5h;

Reference yield: 80.0%

2-Cyano-3-(4-fluoro-phenyl)-3-(2-hydroxy-4,4-dimethyl-6-oxo-cyclohex-1-enyl)-thiopropionamide; compound with morpholine (131270-65-0) → thioamide of 3-(5,5-dimethyl-1-hydroxy-3-oxo-1-cyclohexen-2-yl)-3-(4-fluorophenyl)-2-cyanopropionic acid (104309-80-0)

Guidance literature:

With hydrogenchloride; In ethanol; at 0 ℃;

upstream raw materials:

morpholine

2-cyano-3-(4-fluorophenyl)prop-2-enethioamide

dimedone

(E)-2-cyano-3-(4-fluorophenyl)prop-2-enethioamide

Downstream raw materials:

7,7-dimethyl-5-oxo-4-(4-fluorophenyl)-3-cyano-3,4,5,6,7,8-hexahydro-2(1H)-quinolinethione

4-(4-Fluoro-phenyl)-2-mercapto-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydro-quinoline-3-carbonitrile; compound with morpholine

thioamide of 3-(5,5-dimethyl-1-hydroxy-3-oxo-1-cyclohexen-2-yl)-3-(4-fluorophenyl)-2-cyanopropionic acid

Refernces

• 1、 Goncharenko, M. P.,Sharanin, Yu. A.,Shestopalov, A. M.,Litvinov, V. P.,Turov, A. V.. "CYCLIZATION REACTIONS OF NITRILES. XXVII. THE STRUCTURE AND CONFORMATIONALLY AMBIDENT HETEROCYCLIZATION OF SUBSTITUTED 2-(THIOCARBAMOYL-2-CYANOETHYL)-3-OXO-1-CYCLOHEXENOLATES". . p. 1362 - 1370. Retrieved 2007/10/02.