1-(2-{[6-({4-[{3-[(tert-butoxycarbonyl)(methyl)amino]propyl}(methoxy)carbamoyl]phenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate

Base Information

Chemical Name:1-(2-{[6-({4-[{3-[(tert-butoxycarbonyl)(methyl)amino]propyl}(methoxy)carbamoyl]phenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate
CAS No.:1246248-51-0
Molecular Formula:C₄₄H₆₂N₆O₇
Molecular Weight:787.012
Hs Code.:

1-(2-{[6-({4-[{3-[(tert-butoxycarbonyl)(methyl)amino]propyl}(methoxy)carbamoyl]phenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate

Synonyms:1-(2-{[6-({4-[{3-[(tert-butoxycarbonyl)(methyl)amino]propyl}(methoxy)carbamoyl]phenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate

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Chemical Property of 1-(2-{[6-({4-[{3-[(tert-butoxycarbonyl)(methyl)amino]propyl}(methoxy)carbamoyl]phenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate

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Technology Process of 1-(2-{[6-({4-[{3-[(tert-butoxycarbonyl)(methyl)amino]propyl}(methoxy)carbamoyl]phenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate

There total 6 articles about 1-(2-{[6-({4-[{3-[(tert-butoxycarbonyl)(methyl)amino]propyl}(methoxy)carbamoyl]phenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1246248-50-9
tert-Butyl [3-(methoxyamino)propyl]methylcarbamate

: 1246247-06-2
4-({6-[(2-{4-[(biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-6-oxohexyl}amino)benzoic acid

: 1246248-51-0
1-(2-{[6-({4-[{3-[(tert-butoxycarbonyl)(methyl)amino]propyl}(methoxy)carbamoyl]phenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate

Guidance literature:: With triethylamine; N-methyl-2-chloropyridinium bromide; In dichloromethane; at 50 ℃; for 8h;

Reference yield:

: 98642-44-5
tert-butyl (3-hydroxypropyl)methylcarbamate

: 1246248-51-0
1-(2-{[6-({4-[{3-[(tert-butoxycarbonyl)(methyl)amino]propyl}(methoxy)carbamoyl]phenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0.5 h / Cooling with ice

2: N-ethyl-N,N-diisopropylamine / ethanol / 14 h / 50 °C

3: triethylamine; N-methyl-2-chloropyridinium bromide / dichloromethane / 8 h / 50 °C

With triethylamine; N-ethyl-N,N-diisopropylamine; N-methyl-2-chloropyridinium bromide; In ethanol; dichloromethane;

Reference yield:

: 25542-62-5
6-bromo-hexanoic acid ethyl ester

: 1246248-51-0
1-(2-{[6-({4-[{3-[(tert-butoxycarbonyl)(methyl)amino]propyl}(methoxy)carbamoyl]phenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 72 h / 50 °C

1.2: 96 h / 50 °C

2.1: sodium hydroxide; water / ethanol / 3.5 h / 20 °C

2.3: 1 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 15 h / 20 °C

4.1: triethylamine; N-methyl-2-chloropyridinium bromide / dichloromethane / 8 h / 50 °C

With hydrogenchloride; water; triethylamine; N-ethyl-N,N-diisopropylamine; N-methyl-2-chloropyridinium bromide; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;