1-{2-[{6-[(4-{Methoxy[3-(methylamino)propyl]carbamoyl}phenyl)amino]hexanoyl}(meth yl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate

Base Information

• Chemical Name: 1-{2-[{6-[(4-{Methoxy[3-(methylamino)propyl]carbamoyl}phenyl)amino]hexanoyl}(meth yl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate
• CAS No.: 1246248-52-1
• Molecular Formula: C₃₉H₅₄N₆O₅
• Molecular Weight: 686.895
• Mol file: 1246248-52-1.mol

Synonyms:1-{2-[{6-[(4-{Methoxy[3-(methylamino)propyl]carbamoyl}phenyl)amino]hexanoyl}(meth yl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate

Chemical Property of 1-{2-[{6-[(4-{Methoxy[3-(methylamino)propyl]carbamoyl}phenyl)amino]hexanoyl}(meth yl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-{2-[{6-[(4-{Methoxy[3-(methylamino)propyl]carbamoyl}phenyl)amino]hexanoyl}(meth yl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate

There total 5 articles about 1-{2-[{6-[(4-{Methoxy[3-(methylamino)propyl]carbamoyl}phenyl)amino]hexanoyl}(meth yl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

1-(2-{[6-({4-[{3-[(tert-butoxycarbonyl)(methyl)amino]propyl}(methoxy)carbamoyl]phenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate (1246248-51-0) → 1-{2-[{6-[(4-{Methoxy[3-(methylamino)propyl]carbamoyl}phenyl)amino]hexanoyl}(meth yl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate (1246248-52-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 4h;

Reference yield:

6-bromo-hexanoic acid ethyl ester (25542-62-5) → 1-{2-[{6-[(4-{Methoxy[3-(methylamino)propyl]carbamoyl}phenyl)amino]hexanoyl}(meth yl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate (1246248-52-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 72 h / 50 °C

1.2: 96 h / 50 °C

2.1: sodium hydroxide; water / ethanol / 3.5 h / 20 °C

2.3: 1 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 15 h / 20 °C

4.1: triethylamine; N-methyl-2-chloropyridinium bromide / dichloromethane / 8 h / 50 °C

5.1: hydrogenchloride / 1,4-dioxane; methanol / 4 h / 20 °C

With hydrogenchloride; water; triethylamine; N-ethyl-N,N-diisopropylamine; N-methyl-2-chloropyridinium bromide; sodium hydroxide; In 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

tert-Butyl 4-[(6-ethoxy-6-oxohexyl)amino]benzoate (1246247-04-0) → 1-{2-[{6-[(4-{Methoxy[3-(methylamino)propyl]carbamoyl}phenyl)amino]hexanoyl}(meth yl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate (1246248-52-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydroxide; water / ethanol / 3.5 h / 20 °C

1.3: 1 h / 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 15 h / 20 °C

3.1: triethylamine; N-methyl-2-chloropyridinium bromide / dichloromethane / 8 h / 50 °C

4.1: hydrogenchloride / 1,4-dioxane; methanol / 4 h / 20 °C

With hydrogenchloride; water; triethylamine; N-methyl-2-chloropyridinium bromide; sodium hydroxide; In 1,4-dioxane; methanol; ethanol; dichloromethane;

upstream raw materials:

6-bromo-hexanoic acid ethyl ester

tert-Butyl [3-(methoxyamino)propyl]methylcarbamate

4-({6-[(2-{4-[(biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-6-oxohexyl}amino)benzoic acid

tert-Butyl 4-[(6-ethoxy-6-oxohexyl)amino]benzoate