3-Oxa-1-azaspiro[4.5]decan-2-one,6-methoxy-,(5R,6S)-rel-(9CI)

Base Information

Chemical Name:3-Oxa-1-azaspiro[4.5]decan-2-one,6-methoxy-,(5R,6S)-rel-(9CI)
CAS No.:444772-06-9
Molecular Formula:C₉H₁₅NO₃
Molecular Weight:185.223
Hs Code.:
Mol file:444772-06-9.mol

Synonyms:3-Oxa-1-azaspiro[4.5]decan-2-one,6-methoxy-,(5R,6S)-rel-(9CI)

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Chemical Property of 3-Oxa-1-azaspiro[4.5]decan-2-one,6-methoxy-,(5R,6S)-rel-(9CI)

Chemical Property:

PSA：0.00000
LogP:0.00000

Purity/Quality:

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Technology Process of 3-Oxa-1-azaspiro[4.5]decan-2-one,6-methoxy-,(5R,6S)-rel-(9CI)

There total 5 articles about 3-Oxa-1-azaspiro[4.5]decan-2-one,6-methoxy-,(5R,6S)-rel-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 67-56-1
methanol

: 444772-03-6
tetrahydro-2-oxa-3a-aza-cyclopenta[1,3]cyclopropa[1.2]benzen-3-one

: 444772-06-9
6-methoxy-3-oxa-1-aza-spiro[4.5]decan-2-one

Guidance literature:: toluene-4-sulfonic acid; In methanol; at 20 ℃; for 4h;
DOI:10.1021/ol0259490

Reference yield:

: 1192-88-7
1-cyclohexene-1-carboxaldehyde

: 444772-06-9
6-methoxy-3-oxa-1-aza-spiro[4.5]decan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / LiAlH₄

2: K₂CO₃ / methanol

3: 75 percent / PhIO; molecular sieves / CH₂Cl₂ / 12 h / 40 °C

4: 83 percent / p-TsOH / 4 h / 20 °C

With lithium aluminium tetrahydride; molecular sieve; iodosylbenzene; potassium carbonate; toluene-4-sulfonic acid; In methanol; dichloromethane;
DOI:10.1021/jo048990k

Reference yield:

: 4845-04-9
1-cyclohexene-1-methanol

: 444772-06-9
6-methoxy-3-oxa-1-aza-spiro[4.5]decan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃ / methanol

2: 75 percent / PhIO; molecular sieves / CH₂Cl₂ / 12 h / 40 °C

3: 83 percent / p-TsOH / 4 h / 20 °C

With molecular sieve; iodosylbenzene; potassium carbonate; toluene-4-sulfonic acid; In methanol; dichloromethane;
DOI:10.1021/jo048990k