1H-TETRAZOLE-1-ACETYL CHLORIDE

Base Information

• Chemical Name: 1H-TETRAZOLE-1-ACETYL CHLORIDE
• CAS No.: 41223-92-1
• Molecular Formula: C3H3 Cl N4 O
• Molecular Weight: 146.54
• Mol file: 41223-92-1.mol

Synonyms:1-Tetrazoleacetylchloride; 1-Tetrazolylacetyl chloride; 1H-Tetrazol-1-ylacetyl chloride;2-(1H-Tetrazol-1-yl)acetyl chloride

Chemical Property of 1H-TETRAZOLE-1-ACETYL CHLORIDE

Chemical Property:

• Boiling Point: 263.3±42.0 °C(Predicted)
• PKA: 0.36±0.10(Predicted)
• PSA: 60.67000
• Density: 1.75±0.1 g/cm3(Predicted)
• LogP: -0.56150

Purity/Quality:

98%min ^*data from raw suppliers

1H-Tetrazol-1-ylacetyl chloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-TETRAZOLE-1-ACETYL CHLORIDE

There total 3 articles about 1H-TETRAZOLE-1-ACETYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

1H-tetrazol-1-ylacetic acid (21732-17-2) + oxalyl dichloride (79-37-8) → 2-(tetrazol-1-yl)acetic acid chloride (41223-92-1)

Guidance literature:

In benzene;

Reference yield:

1H-tetrazol-1-ylacetic acid (21732-17-2) → 2-(tetrazol-1-yl)acetic acid chloride (41223-92-1)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In benzene; for 2h; Ambient temperature;

DOI:10.1021/jm00133a018

Reference yield:

→ 2-(tetrazol-1-yl)acetic acid chloride (41223-92-1)

Guidance literature:

1-(1H)-Tetrazolylessigsaeure,PCl5;

DOI:10.7164/antibiotics.23.131

upstream raw materials:

1H-tetrazol-1-ylacetic acid

oxalyl dichloride

Downstream raw materials:

(6R,7S)-3-(5-Methyl-[1,3,4]thiadiazol-2-ylsulfanylmethyl)-8-oxo-7-(2-tetrazol-1-yl-acetylamino)-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

N-(2-(2-(2'-(2-(2-(2-oxo-2-(1H-1,2,3,4-tetrazol-1-yl)ethylamino)ethylthio)ethoxy)biphenyl-2-yloxy)ethylthio)ethyl)-2-(1H-1,2,3,4-tetrazol-1-yl)acetamide

C₁₉H₁₉ClN₆O₅S

2-[(3S,4R)-3-(tert.-butyl-dimethyl-silyloxymethyl)-4-[2-(tetrazol-1-yl)-acetylthio]-2-oxoazetidin-1-yl]-2-triphenylphosphoranylideneacetic acid allyl ester

Refernces

• 1、 -. "METALLO-OXIDOREDUCTASE INHIBITORS USING METAL BINDING MOIETIES IN COMBINATION WITH TARGETING MOIETIES". Page/Page column 148. . Retrieved 2008/12/05.
• 2、 Ternansky,Draheim,Pike,Counter,Eudaly,Kasher. "Structure-activity relationship within a series of pyrazolidinone antibacterial agents. 2. Effect of side-chain modification on in vitro activity and pharmacokinetic parameters". . p. 3224 - 3229. Retrieved 2007/10/02.