(2-AMINO-5-BROMOPYRIDIN-3-YL)METHANOL HYDROBROMIDE

Base Information

• Chemical Name: (2-AMINO-5-BROMOPYRIDIN-3-YL)METHANOL HYDROBROMIDE
• CAS No.: 443956-55-6
• Molecular Formula: BrH*C₆H₇BrN₂O
• Molecular Weight: 283.95
• Hs Code.: 2933399990
• Mol file: 443956-55-6.mol

Synonyms:3-Pyridinemethanol,2-amino-5-bromo-, monohydrobromide (9CI); 2-Amino-5-bromo-3-(hydroxymethyl)pyridinehydrobromide

Chemical Property of (2-AMINO-5-BROMOPYRIDIN-3-YL)METHANOL HYDROBROMIDE

Chemical Property:

• Vapor Pressure: 2.67E-05mmHg at 25°C
• Boiling Point: 343.5°Cat760mmHg
• Flash Point: 161.6°C
• PSA: 59.14000
• Density: g/cm³
• LogP: 2.45790
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-5-bromo-3-(hydroxymethyl)pyridine hydrobromide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of (2-AMINO-5-BROMOPYRIDIN-3-YL)METHANOL HYDROBROMIDE

There total 2 articles about (2-AMINO-5-BROMOPYRIDIN-3-YL)METHANOL HYDROBROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(2-amino-3-pyridinyl)methanol (23612-57-9) → (2-amino-5-bromopyridine-3-yl)methanol hydrobromide (443956-55-6)

Guidance literature:

With bromine; acetic acid; at 20 ℃; Cooling with ice; Inert atmosphere;

Reference yield:

2-aminopyridin-3-carboxylic acid (5345-47-1) → (2-amino-5-bromopyridine-3-yl)methanol hydrobromide (443956-55-6)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / Reflux

2: acetic acid; bromine / 3 h / 20 - 35 °C

With lithium aluminium tetrahydride; bromine; acetic acid; In tetrahydrofuran;

Reference yield: 84.0%

(2-amino-5-bromopyridine-3-yl)methanol hydrobromide (443956-55-6) → 2-amino-5-bromo-3-(bromomethyl)pyridine hydrobromide (335033-38-0)

Guidance literature:

With hydrogen bromide; for 10h; Reflux; Inert atmosphere;

upstream raw materials:

2-aminopyridin-3-carboxylic acid

(2-amino-3-pyridinyl)methanol

Downstream raw materials:

2-amino-5-bromo-3-(bromomethyl)pyridine hydrobromide

6-bromo-2-oxo-1,2,3,4-tetrahydro-1,8-naphthyridine-3-carboxylic acid methyl ester

6-bromo-3,4-dihydro-1,8-naphthyridine-2(1H)-one

tert-butyl 6-bromo-2-oxo-2,4-dihydro-1H-spiro[[1,8]naphthyridine-3,4'-piperidine]-1'-carboxylate