(E)-(beta-((3,5-dibromophenyl)(4-(trifluoromethyl)phenyl)methylene))-gamma,gamma-dimethyl-gamma-butyrolactone

Base Information

Chemical Name:(E)-(beta-((3,5-dibromophenyl)(4-(trifluoromethyl)phenyl)methylene))-gamma,gamma-dimethyl-gamma-butyrolactone
CAS No.:1311274-85-7
Molecular Formula:C₂₀H₁₅Br₂F₃O₂
Molecular Weight:504.141
Hs Code.:

Synonyms:(E)-(beta-((3,5-dibromophenyl)(4-(trifluoromethyl)phenyl)methylene))-gamma,gamma-dimethyl-gamma-butyrolactone

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Chemical Property of (E)-(beta-((3,5-dibromophenyl)(4-(trifluoromethyl)phenyl)methylene))-gamma,gamma-dimethyl-gamma-butyrolactone

Chemical Property:

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Technology Process of (E)-(beta-((3,5-dibromophenyl)(4-(trifluoromethyl)phenyl)methylene))-gamma,gamma-dimethyl-gamma-butyrolactone

There total 8 articles about (E)-(beta-((3,5-dibromophenyl)(4-(trifluoromethyl)phenyl)methylene))-gamma,gamma-dimethyl-gamma-butyrolactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1310355-46-4
(E)-4-(3,5-dibromophenyl)-3-(methoxycarbonyl)-4-(4-(trifluoromethyl)phenyl)but-3-enoic acid

: 676-58-4
methylmagnesium chloride

: 1311274-85-7
(E)-(beta-((3,5-dibromophenyl)(4-(trifluoromethyl)phenyl)methylene))-gamma,gamma-dimethyl-gamma-butyrolactone

Guidance literature:: (E)-4-(3,5-dibromophenyl)-3-(methoxycarbonyl)-4-(4-(trifluoromethyl)phenyl)but-3-enoic acid; methylmagnesium chloride; With lanthanum(III) chloride; lithium chloride; In tetrahydrofuran; at -15 ℃;

With acetic acid; In tetrahydrofuran; water; pH=4;

Reference yield:

: 1310355-46-4
(E)-4-(3,5-dibromophenyl)-3-(methoxycarbonyl)-4-(4-(trifluoromethyl)phenyl)but-3-enoic acid

: 676-58-4
methylmagnesium chloride

: 1311274-85-7
(E)-(beta-((3,5-dibromophenyl)(4-(trifluoromethyl)phenyl)methylene))-gamma,gamma-dimethyl-gamma-butyrolactone

: 1383382-98-6
(Z)-(beta-((3,5-dibromophenyl)(4-(trifluoromethyl)phenyl)methylene))-gamma,gamma-dimethyl-gamma-butyrolactone

Guidance literature:: With lanthanum(III) chloride; lithium chloride; In tetrahydrofuran; at -15 ℃; Reflux;

Reference yield:

: 626-39-1
1,3,5-trisbromobenzene

: 1311274-85-7
(E)-(beta-((3,5-dibromophenyl)(4-(trifluoromethyl)phenyl)methylene))-gamma,gamma-dimethyl-gamma-butyrolactone

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2-methylpropylmagnesium chloride / tetrahydrofuran / 1 h / 0 °C

1.2: 18.08 h / -20 °C

1.3: pH 2

2.1: potassium tert-butylate / toluene / 2.5 h

2.2: pH 2

3.1: lithium chloride; lanthanum(III) chloride / tetrahydrofuran / -15 °C

3.2: pH 4

With lanthanum(III) chloride; 2-methylpropylmagnesium chloride; potassium tert-butylate; lithium chloride; In tetrahydrofuran; toluene; 2.1: Stobbe Condensation;