(2R,4S)-1-(4-tolylsulfonyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-formylpyrrolidine

Base Information

Chemical Name:(2R,4S)-1-(4-tolylsulfonyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-formylpyrrolidine
CAS No.:141621-10-5
Molecular Formula:C₁₈H₂₉NO₄SSi
Molecular Weight:383.584
Hs Code.:

Synonyms:(2R,4S)-1-(4-tolylsulfonyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-formylpyrrolidine

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Chemical Property of (2R,4S)-1-(4-tolylsulfonyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-formylpyrrolidine

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Technology Process of (2R,4S)-1-(4-tolylsulfonyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-formylpyrrolidine

There total 12 articles about (2R,4S)-1-(4-tolylsulfonyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-formylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 142928-26-5
(2R,4S)-1-(4-tolylsulfonyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-<(3,5-dimethyl-1H-pyrazol-1-yl)-carbonyl>pyrrolidine

: 141621-10-5
(2R,4S)-1-(4-tolylsulfonyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-formylpyrrolidine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at -40 ℃; for 0.5h;
DOI:10.1021/jm00093a024

Reference yield: 71.0%

: (2R,4S)-4-(tert-Butyl-dimethyl-silanyloxy)-1-(toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid amide

: 141621-10-5
(2R,4S)-1-(4-tolylsulfonyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-formylpyrrolidine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran;
DOI:10.3987/COM-91-5925

Reference yield:

: 141621-09-2
(2R,4S)-4-(tert-Butyl-dimethyl-silanyloxy)-1-(toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid

: 141621-10-5
(2R,4S)-1-(4-tolylsulfonyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-formylpyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: dicyclohexylcarbodiimide (DCCI) / CHCl₃ / 10 - 20 °C

2: 71 percent / LAH / tetrahydrofuran / 0.5 h / -40 °C

With lithium aluminium tetrahydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; chloroform;
DOI:10.1021/jm00093a024