2-(2-hydroxycyclohexyl)-6-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3(2H)-pyridazinone

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Chemical Name:2-(2-hydroxycyclohexyl)-6-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3(2H)-pyridazinone
CAS No.:247110-27-6
Molecular Formula:C₂₃H₂₂N₄O₂
Molecular Weight:386.453
Hs Code.:

Synonyms:2-(2-hydroxycyclohexyl)-6-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3(2H)-pyridazinone

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Chemical Property of 2-(2-hydroxycyclohexyl)-6-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3(2H)-pyridazinone

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Technology Process of 2-(2-hydroxycyclohexyl)-6-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3(2H)-pyridazinone

There total 1 articles about 2-(2-hydroxycyclohexyl)-6-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3(2H)-pyridazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 171050-40-1
3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-(6H)-pyridazin-6-one-1-cyclohexan-2-one

: 247110-27-6
2-(2-hydroxycyclohexyl)-6-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3(2H)-pyridazinone

Guidance literature:: With lithium tri(t-butoxy)aluminum hydride; In tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dichloromethane; ethyl acetate;

Reference yield: 88.0%

: 247110-27-6
2-(2-hydroxycyclohexyl)-6-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3(2H)-pyridazinone

: 171050-40-1
3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-(6H)-pyridazin-6-one-1-cyclohexan-2-one

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -70 - 20 ℃;
DOI:10.1016/S0040-4020(99)00590-6

Reference yield:

: 247110-27-6
2-(2-hydroxycyclohexyl)-6-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3(2H)-pyridazinone

: 171051-35-7
tert-butyl 6-[6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinyl]-1-cyclohexenylacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 88 percent / dimethyl sulfoxide; oxalyl chloride; triethylamine / CH₂Cl₂ / -70 - 20 °C

2.1: potassium tert-butoxide; 18-crown-6 / toluene / 0.5 h / 4 °C

2.2: 21 percent / toluene / 8 h / 20 °C

3.1: DBU / toluene / 24 h / Heating

With oxalyl dichloride; 18-crown-6 ether; potassium tert-butylate; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In dichloromethane; toluene; 1.1: Swern oxidation / 2.1: Metallation / 2.2: Horner-Emmons reaction / 3.1: Isomerization;
DOI:10.1016/S0040-4020(99)00590-6