(S)-2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethylamine

Base Information

Chemical Name:(S)-2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethylamine
CAS No.:340963-40-8
Molecular Formula:C₂₅H₃₀N₂O₄Si
Molecular Weight:450.61
Hs Code.:

Synonyms:(S)-2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethylamine

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Chemical Property of (S)-2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethylamine

Chemical Property:

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Technology Process of (S)-2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethylamine

There total 7 articles about (S)-2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 340963-75-9
(S)-2-[2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethyl]isoindole-1,3-dione

: 340963-40-8
(S)-2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethylamine

Guidance literature:: With hydrazine hydrate; In ethanol; for 3h; Heating;
DOI:10.1021/jo015512q

Reference yield:

: 82807-38-3
1-(2-methoxyphenyl)ethane-1,2-diol

: 340963-40-8
(S)-2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethylamine

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / pyridine / 8 h / 20 °C

2: 83 percent / KNO₃; TFAA / CHCl₃ / 48 h / 0 °C

3: 93 percent / K₂CO₃ / methanol; H₂O / 0.5 h

4: 73 percent / imidazole / dimethylformamide / 4 h / 20 °C

5: 89 percent / PPh₃; DEAD / tetrahydrofuran / 1.5 h

6: 100 percent / NH₂NH₂*H₂O / ethanol / 3 h / Heating

With 1H-imidazole; potassium carbonate; hydrazine hydrate; potassium nitrate; triphenylphosphine; trifluoroacetic anhydride; diethylazodicarboxylate; In tetrahydrofuran; pyridine; methanol; ethanol; chloroform; water; N,N-dimethyl-formamide; 5: Mitsunobu reaction;
DOI:10.1021/jo015512q

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 340963-40-8
(S)-2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / imidazole / dimethylformamide / 4 h / 20 °C

2: 89 percent / PPh₃; DEAD / tetrahydrofuran / 1.5 h

3: 100 percent / NH₂NH₂*H₂O / ethanol / 3 h / Heating

With 1H-imidazole; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; 2: Mitsunobu reaction;
DOI:10.1021/jo015512q