Technology Process of 7-(2-chlorophenoxy)-5-{[2-ethoxy-4-(pyrrolidin-1-ylmethyl)phenyl]amino}pyrido[3,4-d]pyridazin-4(3H)-one
There total 12 articles about 7-(2-chlorophenoxy)-5-{[2-ethoxy-4-(pyrrolidin-1-ylmethyl)phenyl]amino}pyrido[3,4-d]pyridazin-4(3H)-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: thionyl chloride / 5 h / 20 °C / Cooling with ice
2.1: sodium tris(acetoxy)borohydride / ethanol / 3 h / 80 °C
3.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C
4.1: toluene-4-sulfonic acid / toluene; methanol / 2 h / Reflux
5.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 3 h / -78 °C
5.2: 2 h / 20 °C
6.1: trifluoroacetic acid / dichloromethane / 20 °C
7.1: 1,4-dioxane / 20 °C
8.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
9.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 1.5 h / 120 °C / Sealed tube
10.1: caesium carbonate / copper(l) iodide; dimethylaminoacetic acid / 1,4-dioxane / 15 h / 120 °C / Sealed tube
With
n-butyllithium; thionyl chloride; sodium tris(acetoxy)borohydride; caesium carbonate; Dess-Martin periodane; diisopropylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
copper(l) iodide; dimethylaminoacetic acid; toluene-4-sulfonic acid;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; toluene;
- Guidance literature:
-
With
caesium carbonate;
copper(l) iodide; dimethylaminoacetic acid;
In
1,4-dioxane;
at 120 ℃;
for 15h;
Sealed tube;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: sodium tris(acetoxy)borohydride / ethanol / 3 h / 80 °C
2.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C
3.1: toluene-4-sulfonic acid / toluene; methanol / 2 h / Reflux
4.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 3 h / -78 °C
4.2: 2 h / 20 °C
5.1: trifluoroacetic acid / dichloromethane / 20 °C
6.1: 1,4-dioxane / 20 °C
7.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
8.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 1.5 h / 120 °C / Sealed tube
9.1: caesium carbonate / copper(l) iodide; dimethylaminoacetic acid / 1,4-dioxane / 15 h / 120 °C / Sealed tube
With
n-butyllithium; sodium tris(acetoxy)borohydride; caesium carbonate; Dess-Martin periodane; diisopropylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
copper(l) iodide; dimethylaminoacetic acid; toluene-4-sulfonic acid;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; toluene;
