(S,E)-methyl 2-(2-(((benzyloxy)carbonyl)amino)-N-(4-oxopent-2-en-1-yl)-3-phenylpropanamido)acetate

Base Information

Chemical Name:(S,E)-methyl 2-(2-(((benzyloxy)carbonyl)amino)-N-(4-oxopent-2-en-1-yl)-3-phenylpropanamido)acetate
CAS No.:1334324-80-9
Molecular Formula:C₂₅H₂₈N₂O₆
Molecular Weight:452.507
Hs Code.:

Synonyms:(S,E)-methyl 2-(2-(((benzyloxy)carbonyl)amino)-N-(4-oxopent-2-en-1-yl)-3-phenylpropanamido)acetate

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Chemical Property of (S,E)-methyl 2-(2-(((benzyloxy)carbonyl)amino)-N-(4-oxopent-2-en-1-yl)-3-phenylpropanamido)acetate

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Technology Process of (S,E)-methyl 2-(2-(((benzyloxy)carbonyl)amino)-N-(4-oxopent-2-en-1-yl)-3-phenylpropanamido)acetate

There total 3 articles about (S,E)-methyl 2-(2-(((benzyloxy)carbonyl)amino)-N-(4-oxopent-2-en-1-yl)-3-phenylpropanamido)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1334324-88-7
C₂₃H₂₆N₂O₅

: 78-94-4,25038-87-3
methyl vinyl ketone

: 1334324-80-9
(S,E)-methyl 2-(2-(((benzyloxy)carbonyl)amino)-N-(4-oxopent-2-en-1-yl)-3-phenylpropanamido)acetate

Guidance literature:: With Hoveyda-Grubbs catalyst second generation; In dichloromethane; at 45 ℃; for 6h; Inert atmosphere;
DOI:10.1021/ol202276h

Reference yield:

: 1161-13-3
N-Cbz-L-Phe

: 1334324-80-9
(S,E)-methyl 2-(2-(((benzyloxy)carbonyl)amino)-N-(4-oxopent-2-en-1-yl)-3-phenylpropanamido)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 0 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 0 - 20 °C / Inert atmosphere

3: Hoveyda-Grubbs catalyst second generation / dichloromethane / 6 h / 45 °C / Inert atmosphere

With Hoveyda-Grubbs catalyst second generation; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol202276h

Reference yield:

: 115329-03-8
((S)-1-Allylcarbamoyl-2-phenyl-ethyl)-carbamic acid benzyl ester

: 1334324-80-9
(S,E)-methyl 2-(2-(((benzyloxy)carbonyl)amino)-N-(4-oxopent-2-en-1-yl)-3-phenylpropanamido)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 0 - 20 °C / Inert atmosphere

2: Hoveyda-Grubbs catalyst second generation / dichloromethane / 6 h / 45 °C / Inert atmosphere

With Hoveyda-Grubbs catalyst second generation; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol202276h