endo-tert-butyl 3-(6-(2-fluoro-4-(methylsulfonyl)phenylamino)-5-nitropyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

Base Information

Chemical Name:endo-tert-butyl 3-(6-(2-fluoro-4-(methylsulfonyl)phenylamino)-5-nitropyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate
CAS No.:1424328-56-2
Molecular Formula:C₂₃H₂₈FN₅O₇S
Molecular Weight:537.569
Hs Code.:

Synonyms:endo-tert-butyl 3-(6-(2-fluoro-4-(methylsulfonyl)phenylamino)-5-nitropyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

Suppliers and Price of endo-tert-butyl 3-(6-(2-fluoro-4-(methylsulfonyl)phenylamino)-5-nitropyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of endo-tert-butyl 3-(6-(2-fluoro-4-(methylsulfonyl)phenylamino)-5-nitropyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of endo-tert-butyl 3-(6-(2-fluoro-4-(methylsulfonyl)phenylamino)-5-nitropyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

There total 4 articles about endo-tert-butyl 3-(6-(2-fluoro-4-(methylsulfonyl)phenylamino)-5-nitropyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1310693-13-0
6-chloro-N-(2-fluoro-4-(methylsulfonyl)phenyl)-5-nitropyrimidin-4-amine

: 143557-91-9
(1R,3S,5S)-tert-butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate

: 1424328-56-2
endo-tert-butyl 3-(6-(2-fluoro-4-(methylsulfonyl)phenylamino)-5-nitropyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃; for 5h;
DOI:10.1016/j.bmc.2016.10.030

Reference yield:

: C₁₁H₈ClFN₄O₂S

: 1424328-56-2
endo-tert-butyl 3-(6-(2-fluoro-4-(methylsulfonyl)phenylamino)-5-nitropyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane

2: lithium hexamethyldisilazane / tetrahydrofuran

With 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2012.12.011

Reference yield:

: 76180-33-1
[2-fluoro-4-(methylthio)phenyl]amine

: 1424328-56-2
endo-tert-butyl 3-(6-(2-fluoro-4-(methylsulfonyl)phenylamino)-5-nitropyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane

3: lithium hexamethyldisilazane / tetrahydrofuran

With 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.12.011