3-((S)-3,3-dimethyl-1-(piperidin-1-yl)butan-2-ylamino)-4-(3,5-bis(trifluoromethyl)phenylamino)cyclobut-3-ene-1,2-dione

Base Information

Chemical Name:3-((S)-3,3-dimethyl-1-(piperidin-1-yl)butan-2-ylamino)-4-(3,5-bis(trifluoromethyl)phenylamino)cyclobut-3-ene-1,2-dione
CAS No.:1454257-31-8
Molecular Formula:C₂₃H₂₇F₆N₃O₂
Molecular Weight:491.477
Hs Code.:

Synonyms:3-((S)-3,3-dimethyl-1-(piperidin-1-yl)butan-2-ylamino)-4-(3,5-bis(trifluoromethyl)phenylamino)cyclobut-3-ene-1,2-dione

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Chemical Property of 3-((S)-3,3-dimethyl-1-(piperidin-1-yl)butan-2-ylamino)-4-(3,5-bis(trifluoromethyl)phenylamino)cyclobut-3-ene-1,2-dione

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Technology Process of 3-((S)-3,3-dimethyl-1-(piperidin-1-yl)butan-2-ylamino)-4-(3,5-bis(trifluoromethyl)phenylamino)cyclobut-3-ene-1,2-dione

There total 5 articles about 3-((S)-3,3-dimethyl-1-(piperidin-1-yl)butan-2-ylamino)-4-(3,5-bis(trifluoromethyl)phenylamino)cyclobut-3-ene-1,2-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1223105-85-8
3-(3,5-ditrifluoromethylphenylamino)-4-methoxybutane-3-en-1,2-dione

: 338731-71-8
(S)-3,3-dimethyl-1-(piperidin-1-yl)butan-2-amine

: 1454257-31-8
3-((S)-3,3-dimethyl-1-(piperidin-1-yl)butan-2-ylamino)-4-(3,5-bis(trifluoromethyl)phenylamino)cyclobut-3-ene-1,2-dione

Guidance literature:: In methanol; at 20 ℃;
DOI:10.1016/j.tetasy.2013.07.010

Reference yield:

: tert-butyl (S)-(3,3-dimethyl-1-oxo-1-(piperidin-1-yl)butan-2-yl)carbamate

: 1454257-31-8
3-((S)-3,3-dimethyl-1-(piperidin-1-yl)butan-2-ylamino)-4-(3,5-bis(trifluoromethyl)phenylamino)cyclobut-3-ene-1,2-dione

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 6 h / 40 °C

2: lithium aluminium tetrahydride / diethyl ether / 16 h / 0 - 20 °C / Inert atmosphere

3: methanol / 16 h / 20 °C

With lithium aluminium tetrahydride; trifluoroacetic acid; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/ja510603w

Reference yield:

: 20859-02-3
L-tert-Leucine

: 1454257-31-8
3-((S)-3,3-dimethyl-1-(piperidin-1-yl)butan-2-ylamino)-4-(3,5-bis(trifluoromethyl)phenylamino)cyclobut-3-ene-1,2-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / water; tetrahydrofuran / 12 h / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 1 h

2.2: 16 h

3.1: trifluoroacetic acid / dichloromethane / 6 h / 40 °C

4.1: lithium aluminium tetrahydride / diethyl ether / 16 h / 0 - 20 °C / Inert atmosphere

5.1: methanol / 16 h / 20 °C

With lithium aluminium tetrahydride; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ja510603w