Monoethyl 2-[2-(benzyloxycarbonylamino)-2-(tert-butoxycarbonylamino)ethanoylamino]malonate

Base Information

Chemical Name:Monoethyl 2-[2-(benzyloxycarbonylamino)-2-(tert-butoxycarbonylamino)ethanoylamino]malonate
CAS No.:264913-45-3
Molecular Formula:C₂₀H₂₇N₃O₉
Molecular Weight:453.449
Hs Code.:

Synonyms:Monoethyl 2-[2-(benzyloxycarbonylamino)-2-(tert-butoxycarbonylamino)ethanoylamino]malonate

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Chemical Property of Monoethyl 2-[2-(benzyloxycarbonylamino)-2-(tert-butoxycarbonylamino)ethanoylamino]malonate

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Technology Process of Monoethyl 2-[2-(benzyloxycarbonylamino)-2-(tert-butoxycarbonylamino)ethanoylamino]malonate

There total 2 articles about Monoethyl 2-[2-(benzyloxycarbonylamino)-2-(tert-butoxycarbonylamino)ethanoylamino]malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 264913-44-2
Diethyl [2-(benzyloxycarbonylamino)-2-(tert-butoxycarbonylamino)ethanoylamino]malonate

: 264913-45-3
Monoethyl 2-[2-(benzyloxycarbonylamino)-2-(tert-butoxycarbonylamino)ethanoylamino]malonate

Guidance literature:: With potassium hydroxide; water; In ethanol; at 20 ℃; for 3h;
DOI:10.1039/a904943f

Reference yield:

: 6829-40-9
aminomalonic acid diethyl ester

: 264913-45-3
Monoethyl 2-[2-(benzyloxycarbonylamino)-2-(tert-butoxycarbonylamino)ethanoylamino]malonate

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / HOBT; NEt₃; DCC / dimethylformamide / 12 h / 0 °C / pH 7 - 7.5

2: 98 percent / KOH; H₂O / ethanol / 3 h / 20 °C

With potassium hydroxide; water; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In ethanol; N,N-dimethyl-formamide; 1: Acylation / 2: Hydrolysis;
DOI:10.1039/a904943f