Technology Process of 1,1-dimethoxy-7,9,11-trimethyl-6-[(1E,3E)-4-phenylbuta-1,3-dien-1-yl]heptaleno[4,5-c]furan-3(1H)-one
There total 6 articles about 1,1-dimethoxy-7,9,11-trimethyl-6-[(1E,3E)-4-phenylbuta-1,3-dien-1-yl]heptaleno[4,5-c]furan-3(1H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-methyl hydrogen 6,8,10-trimethyl-1-[(1E,3E)-4-phenylbuta-1,3-dien-1-yl]heptalene-4,5-dicarboxylate;
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
acetonitrile;
methanol;
In
acetonitrile;
DOI:10.1002/hlca.201300137
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium hexamethyldisilazane / tetrahydrofuran / 20 °C / Inert atmosphere
2: lithium hydroxide / methanol; water / 2 h / Reflux
3: N,N-dimethyl-formamide; oxalyl dichloride / acetonitrile
With
oxalyl dichloride; sodium hexamethyldisilazane; N,N-dimethyl-formamide; lithium hydroxide;
In
tetrahydrofuran; methanol; water; acetonitrile;
1: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1002/hlca.201300137
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: toluene / 6 h / 130 °C
1.2: 1 h / 120 °C
2.1: hexachloroethane; potassium tert-butylate / tetrahydrofuran / -78 °C / Inert atmosphere
3.1: sodium iodide / 3 h / 130 °C
4.1: sodium hexamethyldisilazane / tetrahydrofuran / 20 °C / Inert atmosphere
5.1: lithium hydroxide / methanol; water / 2 h / Reflux
6.1: N,N-dimethyl-formamide; oxalyl dichloride / acetonitrile
With
oxalyl dichloride; hexachloroethane; potassium tert-butylate; sodium hexamethyldisilazane; N,N-dimethyl-formamide; sodium iodide; lithium hydroxide;
In
tetrahydrofuran; methanol; water; toluene; acetonitrile;
3.1: |Arbuzov Reaction / 4.1: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1002/hlca.201300137
