α-[2-n-butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazol-5-yl]-α-phenylmethanol

Base Information

Chemical Name:α-[2-n-butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazol-5-yl]-α-phenylmethanol
CAS No.:124751-01-5
Molecular Formula:C₂₈H₂₇ClN₆O
Molecular Weight:499.015
Hs Code.:

Synonyms:α-[2-n-butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazol-5-yl]-α-phenylmethanol

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Chemical Property of α-[2-n-butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazol-5-yl]-α-phenylmethanol

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Technology Process of α-[2-n-butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazol-5-yl]-α-phenylmethanol

There total 12 articles about α-[2-n-butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazol-5-yl]-α-phenylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1348311-05-6
2-Butyl-4-chloro-1-[(2'-N-triphenylmethyl(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole-5-carboxaldehyde

: 100-59-4
phenylmagnesium chloride

: 124751-01-5
α-[2-n-butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazol-5-yl]-α-phenylmethanol

Guidance literature:: With sodium hydroxide; trifluoroacetic acid; In 1,4-dioxane; water;

Reference yield:

: 57598-33-1
2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline

: 124751-01-5
<2-butyl-4-chloro-1-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>imidazol-5-yl>phenylmethanol

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / 2 h / 20 °C

2: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C

3: 1.) tributyltin chloride, sodium azide, 2.) 10 N aq. sodium hydroxide / 1.) toluene, reflux, 70 h, 20 deg C, 3 h

4: 92 percent / N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

5: 49 percent / potassium carbonate / dimethylformamide / 24 h / 25 °C

6: 2.) trifluoroacetic acid / 1.) THF, dioxane, 0 deg C, 1 h, 2.) 25 deg C, 1 h

With pyridine; sodium hydroxide; N-Bromosuccinimide; sodium azide; tributyltin chloride; potassium carbonate; trifluoroacetic acid; trichlorophosphate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00112a031

Reference yield:

: 114772-53-1
2-Cyano-4'-methylbiphenyl

: 124751-01-5
<2-butyl-4-chloro-1-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>imidazol-5-yl>phenylmethanol

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) tributyltin chloride, sodium azide, 2.) 10 N aq. sodium hydroxide / 1.) toluene, reflux, 70 h, 20 deg C, 3 h

2: 92 percent / N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

3: 49 percent / potassium carbonate / dimethylformamide / 24 h / 25 °C

4: 2.) trifluoroacetic acid / 1.) THF, dioxane, 0 deg C, 1 h, 2.) 25 deg C, 1 h

With sodium hydroxide; N-Bromosuccinimide; sodium azide; tributyltin chloride; potassium carbonate; trifluoroacetic acid; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00112a031