6-{4-[7-chloro-4-(4-fluorobenzyl)phthalazin-1-yl]piperazin-1-yl}nicotinonitrile

Base Information

Chemical Name:6-{4-[7-chloro-4-(4-fluorobenzyl)phthalazin-1-yl]piperazin-1-yl}nicotinonitrile
CAS No.:1057679-56-7
Molecular Formula:C₂₅H₂₀ClFN₆
Molecular Weight:458.925
Hs Code.:

Synonyms:6-{4-[7-chloro-4-(4-fluorobenzyl)phthalazin-1-yl]piperazin-1-yl}nicotinonitrile

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Chemical Property of 6-{4-[7-chloro-4-(4-fluorobenzyl)phthalazin-1-yl]piperazin-1-yl}nicotinonitrile

Chemical Property:

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Technology Process of 6-{4-[7-chloro-4-(4-fluorobenzyl)phthalazin-1-yl]piperazin-1-yl}nicotinonitrile

There total 2 articles about 6-{4-[7-chloro-4-(4-fluorobenzyl)phthalazin-1-yl]piperazin-1-yl}nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 223761-28-2
(4-fluorobenzyl)zinc(II) bromide

: 1057682-38-8
6-[4-(4,7-dichlorophthalazin-1-yl)piperazin-1-yl]nicotinonitrile

: 1057682-65-1
6-[4-(4,6-dichlorophthalazin-1-yl)piperazin-1-yl]nicotinonitrile

: 1057679-56-7
6-{4-[7-chloro-4-(4-fluorobenzyl)phthalazin-1-yl]piperazin-1-yl}nicotinonitrile

: 1057679-59-0
6-{4-[6-chloro-4-(4-fluorobenzyl)phthalazin-1-yl]piperazin-1-yl}nicotinonitrile

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 60 ℃; for 0.75h;

Reference yield:

: 149554-29-0
6-piperazin-1-yl-nicotinonitrile

: 178309-37-0
1,4,6-trichlorophthalazine

: 312693-07-5
4-fluorobenzylzinc chloride

: 1057679-56-7
6-{4-[7-chloro-4-(4-fluorobenzyl)phthalazin-1-yl]piperazin-1-yl}nicotinonitrile

: 1057679-59-0
6-{4-[6-chloro-4-(4-fluorobenzyl)phthalazin-1-yl]piperazin-1-yl}nicotinonitrile

Guidance literature:: 6-piperazin-1-yl-nicotinonitrile; 1,4,6-trichlorophthalazine; With triethylamine; In 1-methyl-pyrrolidin-2-one; at 80 ℃; for 2.5h; Inert atmosphere;

4-fluorobenzylzinc chloride; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; Inert atmosphere;
DOI:10.1021/jm900309j

Reference yield:

: 1057679-56-7
6-{4-[7-chloro-4-(4-fluorobenzyl)phthalazin-1-yl]piperazin-1-yl}nicotinonitrile

: 1057679-59-0
6-{4-[6-chloro-4-(4-fluorobenzyl)phthalazin-1-yl]piperazin-1-yl}nicotinonitrile

: 557-21-1
dicyanozinc

: 1057679-63-6
1-[4-(5-cyanopyridin-2-yl)piperazin-1-yl]-4-(4-fluorobenzyl)phthalazine-6-carbonitrile

: 1057679-61-4
4-[4-(5-cyanopyridin-2-yl)piperazin-1-yl]-1-(4-fluorobenzyl)phthalazine-6-carbonitrile

Guidance literature:: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydroxide; In N,N-dimethyl-formamide; at 120 ℃; for 0.75h; Microwave irradiation;