4-[4-(5-cyanopyridin-2-yl)piperazin-1-yl]-1-(4-fluorobenzyl)phthalazine-6-carbonitrile

Base Information

Chemical Name:4-[4-(5-cyanopyridin-2-yl)piperazin-1-yl]-1-(4-fluorobenzyl)phthalazine-6-carbonitrile
CAS No.:1057679-61-4
Molecular Formula:C₂₆H₂₀FN₇
Molecular Weight:449.49
Hs Code.:

Synonyms:4-[4-(5-cyanopyridin-2-yl)piperazin-1-yl]-1-(4-fluorobenzyl)phthalazine-6-carbonitrile

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Chemical Property of 4-[4-(5-cyanopyridin-2-yl)piperazin-1-yl]-1-(4-fluorobenzyl)phthalazine-6-carbonitrile

Chemical Property:

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Technology Process of 4-[4-(5-cyanopyridin-2-yl)piperazin-1-yl]-1-(4-fluorobenzyl)phthalazine-6-carbonitrile

There total 3 articles about 4-[4-(5-cyanopyridin-2-yl)piperazin-1-yl]-1-(4-fluorobenzyl)phthalazine-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1057679-56-7
6-{4-[7-chloro-4-(4-fluorobenzyl)phthalazin-1-yl]piperazin-1-yl}nicotinonitrile

: 1057679-59-0
6-{4-[6-chloro-4-(4-fluorobenzyl)phthalazin-1-yl]piperazin-1-yl}nicotinonitrile

: 557-21-1
dicyanozinc

: 1057679-63-6
1-[4-(5-cyanopyridin-2-yl)piperazin-1-yl]-4-(4-fluorobenzyl)phthalazine-6-carbonitrile

: 1057679-61-4
4-[4-(5-cyanopyridin-2-yl)piperazin-1-yl]-1-(4-fluorobenzyl)phthalazine-6-carbonitrile

Guidance literature:: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydroxide; In N,N-dimethyl-formamide; at 120 ℃; for 0.75h; Microwave irradiation;

Reference yield:

: 557-21-1
zinc(II) cyanide

: 149554-29-0
6-piperazin-1-yl-nicotinonitrile

: 178309-37-0
1,4,6-trichlorophthalazine

: 312693-07-5
4-fluorobenzylzinc chloride

: 1057679-63-6
1-[4-(5-cyanopyridin-2-yl)piperazin-1-yl]-4-(4-fluorobenzyl)phthalazine-6-carbonitrile

: 1057679-61-4
4-[4-(5-cyanopyridin-2-yl)piperazin-1-yl]-1-(4-fluorobenzyl)phthalazine-6-carbonitrile

Guidance literature:: 6-piperazin-1-yl-nicotinonitrile; 1,4,6-trichlorophthalazine; With triethylamine; In 1-methyl-pyrrolidin-2-one; at 80 ℃; for 2.5h; Inert atmosphere;

4-fluorobenzylzinc chloride; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; Inert atmosphere;

zinc(II) cyanide; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In N,N-dimethyl-formamide; at 120 ℃; for 0.75h; Inert atmosphere; Microwave irradiation;
DOI:10.1021/jm900309j

Reference yield:

: 223761-28-2
(4-fluorobenzyl)zinc(II) bromide

: 1057682-38-8
6-[4-(4,7-dichlorophthalazin-1-yl)piperazin-1-yl]nicotinonitrile

: 1057679-61-4
4-[4-(5-cyanopyridin-2-yl)piperazin-1-yl]-1-(4-fluorobenzyl)phthalazine-6-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 0.75 h / 60 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydroxide / N,N-dimethyl-formamide / 0.75 h / 120 °C / Microwave irradiation

tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide;