Technology Process of <6-hydroxy-2-(4-hydroxyphenyl)benzothien-3-yl><4-<2-ethoxy>phenyl>methanone
There total 7 articles about <6-hydroxy-2-(4-hydroxyphenyl)benzothien-3-yl><4-<2-ethoxy>phenyl>methanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
tetrahydrofuran; methanol;
for 24h;
Ambient temperature;
DOI:10.1021/jm00374a021
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 69 percent / PPA / 1 h / 85 - 90 °C
2: 71 percent / pyridine hydrochloride / 6 h / 220 °C
3: 99 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature
4: 76 percent / AlCl3 / 1,2-dichloro-ethane / 16 h
5: 70 percent / 5 N aq. NaOH / tetrahydrofuran; methanol / 24 h / Ambient temperature
With
pyridine; dmap; sodium hydroxide; aluminium trichloride; pyridine hydrochloride;
In
tetrahydrofuran; methanol; 1,2-dichloro-ethane;
DOI:10.1021/jm00374a021
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 80.4 percent / KOH / ethanol; H2O; ethyl acetate / Ambient temperature
2: 69 percent / PPA / 1 h / 85 - 90 °C
3: 71 percent / pyridine hydrochloride / 6 h / 220 °C
4: 99 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature
5: 76 percent / AlCl3 / 1,2-dichloro-ethane / 16 h
6: 70 percent / 5 N aq. NaOH / tetrahydrofuran; methanol / 24 h / Ambient temperature
With
pyridine; dmap; potassium hydroxide; sodium hydroxide; aluminium trichloride; pyridine hydrochloride;
In
tetrahydrofuran; methanol; ethanol; water; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1021/jm00374a021