methyl 3-(4-((tert-butoxycarbonylamino)methyl)phenoxy)propionate

Base Information

• Chemical Name: methyl 3-(4-((tert-butoxycarbonylamino)methyl)phenoxy)propionate
• CAS No.: 1290056-37-9
• Molecular Formula: C₁₆H₂₃NO₅
• Molecular Weight: 309.362
• Mol file: 1290056-37-9.mol

Synonyms:methyl 3-(4-((tert-butoxycarbonylamino)methyl)phenoxy)propionate

Chemical Property of methyl 3-(4-((tert-butoxycarbonylamino)methyl)phenoxy)propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of methyl 3-(4-((tert-butoxycarbonylamino)methyl)phenoxy)propionate

There total 3 articles about methyl 3-(4-((tert-butoxycarbonylamino)methyl)phenoxy)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) + tert-butyl (4-hydroxybenzyl)carbamate (149505-94-2) → methyl 3-(4-((tert-butoxycarbonylamino)methyl)phenoxy)propionate (1290056-37-9)

Guidance literature:

With sodium; hydroquinone; for 48h; Product distribution / selectivity; Inert atmosphere; Reflux;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → methyl 3-(4-((tert-butoxycarbonylamino)methyl)phenoxy)propionate (1290056-37-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2: sodium; hydroquinone / 48 h / Inert atmosphere; Reflux

With sodium; triethylamine; hydroquinone; In dichloromethane;

Reference yield:

4-aminomethylphenol (696-60-6) → methyl 3-(4-((tert-butoxycarbonylamino)methyl)phenoxy)propionate (1290056-37-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2: sodium; hydroquinone / 48 h / Inert atmosphere; Reflux

With sodium; triethylamine; hydroquinone; In dichloromethane;

upstream raw materials:

di-tert-butyl dicarbonate

4-aminomethylphenol

acrylic acid methyl ester

tert-butyl (4-hydroxybenzyl)carbamate