N-[(phenylmethoxy)carbonyl]-L-isoleucine-(1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester

Base Information

Chemical Name:N-[(phenylmethoxy)carbonyl]-L-isoleucine-(1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester
CAS No.:1072902-88-5
Molecular Formula:C₃₆H₅₉NO₆
Molecular Weight:601.868
Hs Code.:

Synonyms:N-[(phenylmethoxy)carbonyl]-L-isoleucine-(1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester

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Chemical Property of N-[(phenylmethoxy)carbonyl]-L-isoleucine-(1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester

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Technology Process of N-[(phenylmethoxy)carbonyl]-L-isoleucine-(1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester

There total 2 articles about N-[(phenylmethoxy)carbonyl]-L-isoleucine-(1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 3160-59-6
N-Cbz-L-Isoleucine

: 104871-99-0,104872-00-6,104872-03-9,104872-05-1,104872-06-2,104872-07-3,104872-19-7,68711-40-0
(3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one

: 1072902-88-5
N-[(phenylmethoxy)carbonyl]-L-isoleucine-(1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester

Guidance literature:: N-Cbz-L-Isoleucine; With dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 0.25h;

(3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one; With dmap; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm800978m

Reference yield:

: 73-32-5,959215-79-3,18875-42-8
L-isoleucine

: 31139-36-3
dibenzyl dicarbonate

: 1072902-88-5
N-[(phenylmethoxy)carbonyl]-L-isoleucine-(1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / 1,4-dioxane

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmcl.2012.05.101

Reference yield:

: 1072902-88-5
N-[(phenylmethoxy)carbonyl]-L-isoleucine-(1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester

: 1072902-75-0
OMDM-188

Guidance literature:: Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / tetrahydrofuran

2: dichloromethane

With palladium on activated charcoal; hydrogen; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2012.05.101