2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one O-3-hydroxybenzoyloxime

Base Information

Chemical Name:2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one O-3-hydroxybenzoyloxime
CAS No.:1461755-61-2
Molecular Formula:C₂₇H₂₈N₂O₅
Molecular Weight:460.53
Hs Code.:

Synonyms:2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one O-3-hydroxybenzoyloxime

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Chemical Property of 2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one O-3-hydroxybenzoyloxime

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Technology Process of 2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one O-3-hydroxybenzoyloxime

There total 4 articles about 2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one O-3-hydroxybenzoyloxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.56%

: 40812-76-8
3-hydroxybenzoyl chloride

: 1461755-51-0
2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one oxime

: 1461755-61-2
2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one O-3-hydroxybenzoyloxime

Guidance literature:: 2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one oxime; With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 0.416667h;

3-hydroxybenzoyl chloride; In N,N-dimethyl-formamide; at 20 ℃; for 8h;
DOI:10.1007/s00044-013-0793-z

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 1461755-61-2
2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one O-3-hydroxybenzoyloxime

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium acetate / ethanol / Heating

2.1: potassium carbonate / acetone / 4 h / Reflux

3.1: sodium acetate trihydrate / ethanol / 0.25 h / Heating

3.2: 2 h / Reflux

4.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.42 h / 20 °C

4.2: 8 h / 20 °C

With potassium tert-butylate; ammonium acetate; sodium acetate trihydrate; potassium carbonate; In ethanol; N,N-dimethyl-formamide; acetone; 1.1: |Mannich Aminomethylation;
DOI:10.1007/s00044-013-0793-z

Reference yield:

: 199285-47-7
2,6-bis(4-methoxyphenyl)piperidin-4-one

: 1461755-61-2
2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one O-3-hydroxybenzoyloxime

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / 4 h / Reflux

2.1: sodium acetate trihydrate / ethanol / 0.25 h / Heating

2.2: 2 h / Reflux

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.42 h / 20 °C

3.2: 8 h / 20 °C

With potassium tert-butylate; sodium acetate trihydrate; potassium carbonate; In ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1007/s00044-013-0793-z