(S_P)-5'-O-DMT-thymidine-3'-O-((4,6-dimethoxy-1,3,5-triazin-2-yl)methylphosphonothioate)

Base Information

• Chemical Name: (S_P)-5'-O-DMT-thymidine-3'-O-((4,6-dimethoxy-1,3,5-triazin-2-yl)methylphosphonothioate)
• CAS No.: 959156-14-0
• Molecular Formula: C₃₇H₄₀N₅O₁₀PS
• Molecular Weight: 777.792

Synonyms:(S_P)-5'-O-DMT-thymidine-3'-O-((4,6-dimethoxy-1,3,5-triazin-2-yl)methylphosphonothioate)

Chemical Property of (S_P)-5'-O-DMT-thymidine-3'-O-((4,6-dimethoxy-1,3,5-triazin-2-yl)methylphosphonothioate)

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Technology Process of (S_P)-5'-O-DMT-thymidine-3'-O-((4,6-dimethoxy-1,3,5-triazin-2-yl)methylphosphonothioate)

There total 3 articles about (S_P)-5'-O-DMT-thymidine-3'-O-((4,6-dimethoxy-1,3,5-triazin-2-yl)methylphosphonothioate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (3945-69-5) + triethylammonium (RP)-5'-O-DMT-thymidine-3'-O-methylphosphonothioate → (SP)-5'-O-DMT-thymidine-3'-O-((4,6-dimethoxy-1,3,5-triazin-2-yl)methylphosphonothioate) (959156-14-0)

Guidance literature:

In acetonitrile; at 20 ℃; for 0.5h;

DOI:10.1021/jo7014906

Reference yield:

(RP)-5'-O-DMT-thymidine-3'-O-methylphosphonothioate + 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (3945-69-5) → (SP)-5'-O-DMT-thymidine-3'-O-((4,6-dimethoxy-1,3,5-triazin-2-yl)methylphosphonothioate) (959156-14-0)

Guidance literature:

In acetonitrile; at 20 ℃;

DOI:10.1021/jo7014906

Reference yield:

triethylammonium 5'-O-DMT-thymidine-3'-O-methylphosphonothioate + 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (3945-69-5) → (RP)-5'-O-DMT-thymidine-3'-O-((4,6-dimethoxy-1,3,5-triazin-2-yl)methylphosphonothioate) (959156-15-1) + (SP)-5'-O-DMT-thymidine-3'-O-((4,6-dimethoxy-1,3,5-triazin-2-yl)methylphosphonothioate) (959156-14-0)

Guidance literature:

In acetonitrile; at 20 ℃; for 0.5h;

DOI:10.1021/jo7014906

upstream raw materials:

4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

Downstream raw materials:

(S)-Methyl-phosphonothioic acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester O-methyl ester

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