3945-69-5Relevant articles and documents
4-(4,6-dimethoxy[1,3,5]triazin-2-yl)-4-methyl-morpholinium chloride (DMTMM): A valuable alternative to PyBOP for solid phase peptide synthesis
Falchi, Alessandro,Giacomelli, Giampaolo,Porcheddu, Andrea,Taddei, Maurizio
, p. 275 - 277 (2000)
The salt formed from 2-chloro-4,6-dimethoxy[1,3,5]triazine and N- methylmorpholine (DMTMM) is an effective coupling agent for solid phase peptide synthesis that can be used as economical alternative to PyBOP. Several oligopeptides were prepared on a Wang type resin using this reagent and the yields and purity of the products were always comparable with those obtained with PyBOP as the coupling agent.
Polypyrrole nanotubes conjugated with human olfactory receptors: High-Performance transducers for FET-Type bioelectronic noses
Lee, Sang Hun,Song, Hyun Seok,Oh, Eun Hae,Park, Tai Hyun,Yoon, Wyeonseok,Kwon, Oh Seok,Jang, Jyongsik
, p. 2755 - 2758 (2009)
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Bifunctional copper(II) chelators from the coupling of the encapsulating ligand 1-methyl-8-amino-3,13,16-trithia-6,10,19-triazabicyclo[6.6.6]icosane (AMN3S3sar) with carboxylic acids; Applications of the coupling agent DMT-MM
Lee, Hui Hui,Lim, Peiying Alinia,Vu, Hoan,Poulsen, Sally-Ann,Gahan, Lawrence R.
, p. 627 - 634 (2015)
Reaction of 1-methyl-8-amino-3,13,16-trithia-6,10,19-triazabicyclo[6.6.6]icosane (AMN3S3sar) with the amide coupling agent 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM) and 4-nitrobenzoic acid, the protected amine 4-(1,3-dioxoisoindolin-2-yl)benzoic acid and the tricarboxylic acid, benzene-1,3,5-tricarboxylic acid (trimesic acid) resulted in the three new ligands N3S3amideSarArNO2, N3S3amideSarAr, and (AMN3S3sar)3TMA. Two of the respective copper(II) complexes have been isolated and characterized.
Phosphorus-Based Organocatalysis for the Dehydrative Cyclization of N-(2-Hydroxyethyl)amides into 2-Oxazolines
Foo, Siong Wan,Mori, Shogo,Ogawa, Saeko,Saito, Susumu,Soleymani Movahed, Farzaneh
, (2021/12/17)
A metal-free, biomimetic catalytic protocol for the cyclization of N-(2-hydroxyethyl)amides to the corresponding 2-oxazolines (4,5-dihydrooxazoles), promoted by the 1,3,5,2,4,6-triazatriphosphorine (TAP)-derived organocatalyst tris(o-phenylenedioxy)cyclotriphosphazene (TAP-1) has been developed. This approach requires less precatalyst compared to the reported relevant systems, with respect to the phosphorus atom (the maximum turnover number (TON) ～30), and exhibits a broader substrate scope and higher functional-group tolerance, providing the functionalized 2-oxazolines with retention of the configuration at the C(4) stereogenic center of the 2-oxazolines. Widely accessible β-amino alcohols can be used in this approach, and the cyclization of N-(2-hydroxyethyl)amides provides the desired 2-oxazolines in up to 99% yield. The mechanism of the reaction was studied by monitoring the reaction using spectral and analytical methods, whereby an 18O-labeling experiment furnished valuable insights. The initial step involves a stoichiometric reaction between the substrate and TAP-1, which leads to the in situ generation of the catalyst, a catechol cyclic phosphate, as well as to a pyrocatechol phosphate and two possible active intermediates. The dehydrative cyclization was also successfully conducted on the gram scale.
POLYPEPT(O)ID-BASED GRAFT COPOLYMERS FOR IN VIVO IMAGING BY TETRAZINE TRANSCYCLOOCTENE CLICK CHEMISTRY
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Page/Page column 11, (2020/01/24)
There is provided novel polypeptide-based carrier systems, which make it possible to label polymeric nanoparticles in the living organism. This enables new approaches in tumor diagnostics (high signal to background ratio) and radiotherapy (radiotherapy of solid tumors). The polypeptide-based carrier system comprises a polypept(o)idic comb (graft) copolymer, and one or more tetrazine bioorthogonal functional groups each linked to a diagnostic agent.
