4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium chloride

Base Information

• Chemical Name: 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium chloride
• CAS No.: 3945-69-5
• Molecular Formula: C10H17 N4 O3 . Cl
• Molecular Weight: 276.723
• Hs Code.: 29349990
• European Community (EC) Number: 447-230-1,629-542-1
• UNII: BLD6N6AV8L
• DSSTox Substance ID: DTXSID50370104
• Wikipedia: DMTMM
• Mol file: 3945-69-5.mol

Synonyms:4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride;DMT-MM

Chemical Property of 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium chloride

Chemical Property:

• Appearance/Colour: white powder
• Melting Point: 118-120 ºC
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 75.59000
• Density: g/cm³
• LogP: -3.10440
• Storage Temp.: -20°C
• Water Solubility.: Soluble in water, Methanol.
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 3
• Exact Mass: 276.0989181
• Heavy Atom Count: 18
• Complexity: 236

Purity/Quality:

99% ^*data from raw suppliers

4-(4,6-Dimethoxy-s-triazin-2-yl)-4-methyl-morpholiniumChloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 22-34-40-20/21/22
• Safety Statements: 26-36/37/39-45

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C[N+]1(CCOCC1)C2=NC(=NC(=N2)OC)OC.[Cl-]
• Uses: DMTMM, a conjugating agent that efficiently conjugat PnPS to Luminex microspheres without affecting the antigenicity of a broad set of PnPS. 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride hydrate is used as a pharmaceutical intermediate. It is used as a reagent for activating carboxylic acids in solution and solid phase peptide synthesis. 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride can be used as a condensing agent for the following transformations:Condensation of carboxylic acids and amines to the corresponding amides in tetrahydrofuran.Esterification of carboxylic acids with alcohols to the corresponding esters.Conversion of carboxylic acids to the corresponding Weinreb amides in protic solvents.

Technology Process of 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium chloride

There total 5 articles about 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methyl-morpholine (109-02-4) + 2-chloro-4,6-dimethoxy-1 ,3,5-triazine (3140-73-6) → 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (3945-69-5)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1016/S0040-4039(99)00968-5

Reference yield: 97.4%

2-chloro-4,6-dimethoxy-1 ,3,5-triazine (3140-73-6) → 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (3945-69-5)

Guidance literature:

With 4-methyl-morpholine; In tetrahydrofuran; methanol;

Reference yield: 95.0%

4-methyl-morpholine (109-02-4) + 2-chloro-4,6-dimethoxy-1 ,3,5-triazine (3140-73-6) → 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-morpholine (241483-00-1) + 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (3945-69-5)

Guidance literature:

In dichloromethane; at 20 ℃; for 17h;

DOI:10.1016/S0040-4020(99)00809-1

upstream raw materials:

4-methyl-morpholine

2-chloro-4,6-dimethoxy-1 ,3,5-triazine

butyric acid

methanol

Downstream raw materials:

2-tert-butoxycarbonylamino-3-phenyl-propionic acid 4,6-dimethoxy-[1,3,5]triazin-2-yl ester

2-(benzyloxy)-4,6-dimethoxy-1,3,5-triazin

(S)-methyl 2-((S)-2-(tert-butoxycarbonylamino)-3-phenylpropanamido)-3-phenylpropanoate

(S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester

Refernces

• 1、 Fan, Fei,Zhang, Ping,Wang, Lihao,Sun, Tiantian,Cai, Chao,Yu, Guangli. "Synthesis and Properties of Functional Glycomimetics through Click Grafting of Fucose onto Chondroitin Sulfates". . . Retrieved 2019.
• 2、 Hao, Jinkun,Li, Zhiyong,Cheng, He,Wu, Chi,Han, Charles C.. "Kinetically driven intra-and interchain association of hydrophobically and hydrophilically modified poly(acrylic acid) in dilute aqueous solutions". . p. 9534 - 9540. Retrieved 2010.
• 3、 Morandini, Andrea,Leonetti, Benedetta,Riello, Pietro,Sole, Roberto,Gatto, Vanessa,Caligiuri, Isabella,Rizzolio, Flavio,Beghetto, Valentina. "Synthesis and Antimicrobial Evaluation of Bis-morpholine Triazine Quaternary Ammonium Salts". supporting information. p. 3172 - 3176. Retrieved 2021/08/03.
• 4、 Griffiths, Rhys C.,Smith, Frances R.,Long, Jed E.,Williams, Huw E. L.,Layfield, Robert,Mitchell, Nicholas J.. "Site-Selective Modification of Peptides and Proteins via Interception of Free-Radical-Mediated Dechalcogenation". supporting information. p. 23659 - 23667. Retrieved 2020/10/21.