ethyl [3-(4-chlorophenylsulfanyl)-4-(hydroxyimino)-2-methyl-4,5,6,7-tetrahydro-1H-indol-1-yl]acetate

Base Information

Chemical Name:ethyl [3-(4-chlorophenylsulfanyl)-4-(hydroxyimino)-2-methyl-4,5,6,7-tetrahydro-1H-indol-1-yl]acetate
CAS No.:1260673-30-0
Molecular Formula:C₁₉H₂₁ClN₂O₃S
Molecular Weight:392.906
Hs Code.:

Synonyms:ethyl [3-(4-chlorophenylsulfanyl)-4-(hydroxyimino)-2-methyl-4,5,6,7-tetrahydro-1H-indol-1-yl]acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl [3-(4-chlorophenylsulfanyl)-4-(hydroxyimino)-2-methyl-4,5,6,7-tetrahydro-1H-indol-1-yl]acetate

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Technology Process of ethyl [3-(4-chlorophenylsulfanyl)-4-(hydroxyimino)-2-methyl-4,5,6,7-tetrahydro-1H-indol-1-yl]acetate

There total 5 articles about ethyl [3-(4-chlorophenylsulfanyl)-4-(hydroxyimino)-2-methyl-4,5,6,7-tetrahydro-1H-indol-1-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.3%

: 1142-19-4
4,4'-dichlorodiphenyl disulfide

: 1260673-29-7
ethyl (2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)acetate

: 1260673-30-0
ethyl [3-(4-chlorophenylsulfanyl)-4-(hydroxyimino)-2-methyl-4,5,6,7-tetrahydro-1H-indol-1-yl]acetate

Guidance literature:: 4,4'-dichlorodiphenyl disulfide; With sulfuryl dichloride; In ethyl acetate; at 0 ℃; for 1h; Inert atmosphere;

ethyl (2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)acetate; In ethyl acetate; for 0.5h; Inert atmosphere;

With tributyl-amine; hydroxylamine hydrochloride; In ethanol; at 20 - 60 ℃; Product distribution / selectivity; Inert atmosphere;

Reference yield:

: 1260673-31-1
ethyl [3-(4-chlorophenylsulfanyl)-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl]acetate

: 1260673-30-0
ethyl [3-(4-chlorophenylsulfanyl)-4-(hydroxyimino)-2-methyl-4,5,6,7-tetrahydro-1H-indol-1-yl]acetate

Guidance literature:: With tributyl-amine; hydroxylamine hydrochloride; In ethanol; at 60 ℃; for 3.5h; Inert atmosphere;
DOI:10.1021/op300173z

Reference yield:

: 90534-62-6
2-(2-oxopropyl)cyclohexane-1,3-dione

: 1260673-30-0
ethyl [3-(4-chlorophenylsulfanyl)-4-(hydroxyimino)-2-methyl-4,5,6,7-tetrahydro-1H-indol-1-yl]acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium acetate / ethanol; water / 2 h / Reflux; Inert atmosphere; Industry scale

2.1: sulfuryl dichloride / ethyl acetate / 1 h / 0 °C / Inert atmosphere

2.2: 0.5 h / Inert atmosphere

2.3: 20 - 60 °C / Inert atmosphere

With sulfuryl dichloride; sodium acetate; In ethanol; water; ethyl acetate;