2-(4-(8-(6-amino-5-(trifluoromethyl)pyridin-3-yl)-[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)phenyl)-2-methylpropanenitrile

Base Information

Chemical Name:2-(4-(8-(6-amino-5-(trifluoromethyl)pyridin-3-yl)-[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)phenyl)-2-methylpropanenitrile
CAS No.:1366047-63-3
Molecular Formula:C₂₅H₁₈F₃N₇
Molecular Weight:473.46
Hs Code.:

Synonyms:2-(4-(8-(6-amino-5-(trifluoromethyl)pyridin-3-yl)-[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)phenyl)-2-methylpropanenitrile

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Chemical Property of 2-(4-(8-(6-amino-5-(trifluoromethyl)pyridin-3-yl)-[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)phenyl)-2-methylpropanenitrile

Chemical Property:

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Technology Process of 2-(4-(8-(6-amino-5-(trifluoromethyl)pyridin-3-yl)-[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)phenyl)-2-methylpropanenitrile

There total 8 articles about 2-(4-(8-(6-amino-5-(trifluoromethyl)pyridin-3-yl)-[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)phenyl)-2-methylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 947249-01-6
5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3-trifluoromethyl-pyridin-2-ylamine

: 1190705-75-9
2-(4-(8-bromo-[1,2,4]triazolo[4,3-a]quinoxalin-1-yl) phenyl)-2-methylpropanenitrile

: 1366047-63-3
2-(4-(8-(6-amino-5-(trifluoromethyl)pyridin-3-yl)-[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 150 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 79456-34-1
5-bromo-3-(trifluoromethyl)pyridin-2-amine

: 1366047-63-3
2-(4-(8-(6-amino-5-(trifluoromethyl)pyridin-3-yl)-[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate / 1,4-dioxane / 10 h / 110 °C / Inert atmosphere

2: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium carbonate / 1,4-dioxane; water / 0.5 h / 150 °C / Microwave irradiation

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; potassium carbonate; In 1,4-dioxane; water;

Reference yield:

: 1196-57-2,144499-26-3
2-hydroxyquinoxaline

: 1366047-63-3
2-(4-(8-(6-amino-5-(trifluoromethyl)pyridin-3-yl)-[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 6 steps

1: bromine / 6 h / 20 °C

2: trichlorophosphate / N,N-dimethyl-formamide / 3 h / 100 °C

3: hydrazine / ethanol / 2 h / 78 °C

4: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

5: sodium hydrogencarbonate / acetic acid / 100 °C

6: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium carbonate / 1,4-dioxane; water / 0.5 h / 150 °C / Microwave irradiation

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; bromine; sodium hydrogencarbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; hydrazine; trichlorophosphate; In 1,4-dioxane; ethanol; water; acetic acid; N,N-dimethyl-formamide;