(2S)-3-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulphanyl)-3,5-dicyanopyridin-4-yl]phenoxy}propane-1,2-diyl bis{6-[(tert-butoxycarbonyl)amino]hexanoate}

Base Information

Chemical Name:(2S)-3-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulphanyl)-3,5-dicyanopyridin-4-yl]phenoxy}propane-1,2-diyl bis{6-[(tert-butoxycarbonyl)amino]hexanoate}
CAS No.:1229002-55-4
Molecular Formula:C₄₈H₅₈ClN₇O₁₀S
Molecular Weight:960.548
Hs Code.:

(2S)-3-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulphanyl)-3,5-dicyanopyridin-4-yl]phenoxy}propane-1,2-diyl bis{6-[(tert-butoxycarbonyl)amino]hexanoate}

Synonyms:(2S)-3-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulphanyl)-3,5-dicyanopyridin-4-yl]phenoxy}propane-1,2-diyl bis{6-[(tert-butoxycarbonyl)amino]hexanoate}

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Chemical Property of (2S)-3-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulphanyl)-3,5-dicyanopyridin-4-yl]phenoxy}propane-1,2-diyl bis{6-[(tert-butoxycarbonyl)amino]hexanoate}

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Technology Process of (2S)-3-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulphanyl)-3,5-dicyanopyridin-4-yl]phenoxy}propane-1,2-diyl bis{6-[(tert-butoxycarbonyl)amino]hexanoate}

There total 7 articles about (2S)-3-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulphanyl)-3,5-dicyanopyridin-4-yl]phenoxy}propane-1,2-diyl bis{6-[(tert-butoxycarbonyl)amino]hexanoate} which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 6404-29-1
6-(tert-butoxycarbonylamino)hexanoic acid

: 1107662-18-9
2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulfanyl)-4-(4-{[(2R)-2,3-dihydroxypropyl]oxy}phenyl)pyridine-3,5-dicarbonitrile

: 1229002-55-4
(2S)-3-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulphanyl)-3,5-dicyanopyridin-4-yl]phenoxy}propane-1,2-diyl bis{6-[(tert-butoxycarbonyl)amino]hexanoate}

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 22091-36-7
4-chloromethyl-2-(4-chlorophenyl)oxazole

: 1229002-55-4
(2S)-3-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulphanyl)-3,5-dicyanopyridin-4-yl]phenoxy}propane-1,2-diyl bis{6-[(tert-butoxycarbonyl)amino]hexanoate}

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 h / 20 °C

2: hydrogenchloride; water / ethanol / Reflux

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

With hydrogenchloride; dmap; water; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1229002-55-4
(2S)-3-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulphanyl)-3,5-dicyanopyridin-4-yl]phenoxy}propane-1,2-diyl bis{6-[(tert-butoxycarbonyl)amino]hexanoate}

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 160 °C / Inert atmosphere

2: 4-methyl-morpholine / ethanol / 19 h / 20 °C / Reflux

3: sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 h / 20 °C

4: hydrogenchloride; water / ethanol / Reflux

5: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; dmap; water; sodium hydrogencarbonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; N,N-dimethyl-formamide;