(E)-1-(6-chloro-2-methyl-4-phenylquinolin-3-yl)-3-(4-fluorophenyl)prop-2-en-1-one

Base Information

Chemical Name:(E)-1-(6-chloro-2-methyl-4-phenylquinolin-3-yl)-3-(4-fluorophenyl)prop-2-en-1-one
CAS No.:1370723-74-2
Molecular Formula:C₂₅H₁₇ClFNO
Molecular Weight:401.867
Hs Code.:

Synonyms:(E)-1-(6-chloro-2-methyl-4-phenylquinolin-3-yl)-3-(4-fluorophenyl)prop-2-en-1-one

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Chemical Property of (E)-1-(6-chloro-2-methyl-4-phenylquinolin-3-yl)-3-(4-fluorophenyl)prop-2-en-1-one

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Technology Process of (E)-1-(6-chloro-2-methyl-4-phenylquinolin-3-yl)-3-(4-fluorophenyl)prop-2-en-1-one

There total 2 articles about (E)-1-(6-chloro-2-methyl-4-phenylquinolin-3-yl)-3-(4-fluorophenyl)prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 459-57-4
4-fluorobenzaldehyde

: 719-59-5
5-chloro-2-aminobenzophenone

: 123-54-6,81235-32-7
acetylacetone

: 1370723-74-2
(E)-1-(6-chloro-2-methyl-4-phenylquinolin-3-yl)-3-(4-fluorophenyl)prop-2-en-1-one

Guidance literature:: 5-chloro-2-aminobenzophenone; acetylacetone; In ethanol; at 200 ℃; for 1h; Microwave irradiation;

4-fluorobenzaldehyde; With sodium hydroxide; In ethanol; at 200 ℃; for 1h; Microwave irradiation;
DOI:10.1055/s-0039-1690088

Reference yield: 82.0%

: 22609-02-5
1-(6-chloro-2-methyl-4-phenylquinolin-3-yl)ethanone

: 459-57-4
4-fluorobenzaldehyde

: 1370723-74-2
(E)-1-(6-chloro-2-methyl-4-phenylquinolin-3-yl)-3-(4-fluorophenyl)prop-2-en-1-one

Guidance literature:: With aluminum oxide; for 0.0666667h; Microwave irradiation;
DOI:10.1002/jccs.201100162

Reference yield: 78.0%

: 1370723-74-2
(E)-1-(6-chloro-2-methyl-4-phenylquinolin-3-yl)-3-(4-fluorophenyl)prop-2-en-1-one

: 1244950-80-8
C₃₁H₂₃ClFN₃

Guidance literature:: With phenylhydrazine; potassium hydroxide; In methanol; for 0.166667h; Microwave irradiation;
DOI:10.1002/jccs.201100162