(3S,4S,E)-7-(4-methoxybenzyloxy)-3,5-dimethyl-1-(trimethylsilyl)hept-5-en-1-yn-4-ol

Base Information

Chemical Name:(3S,4S,E)-7-(4-methoxybenzyloxy)-3,5-dimethyl-1-(trimethylsilyl)hept-5-en-1-yn-4-ol
CAS No.:1283713-43-8
Molecular Formula:C₂₀H₃₀O₃Si
Molecular Weight:346.542
Hs Code.:

Synonyms:(3S,4S,E)-7-(4-methoxybenzyloxy)-3,5-dimethyl-1-(trimethylsilyl)hept-5-en-1-yn-4-ol

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Chemical Property of (3S,4S,E)-7-(4-methoxybenzyloxy)-3,5-dimethyl-1-(trimethylsilyl)hept-5-en-1-yn-4-ol

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Technology Process of (3S,4S,E)-7-(4-methoxybenzyloxy)-3,5-dimethyl-1-(trimethylsilyl)hept-5-en-1-yn-4-ol

There total 1 articles about (3S,4S,E)-7-(4-methoxybenzyloxy)-3,5-dimethyl-1-(trimethylsilyl)hept-5-en-1-yn-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 200440-90-0
((3R)-3-{[dihydroxy(methyl)-λ⁴-sulfanyl]oxy}but-1-yn-1-yl)(trimethyl)silane

: 197227-70-6
(2E)-4-[(4-methoxybenzyl)oxy]-2-methylbut-2-enal

: 1283713-43-8
(3S,4S,E)-7-(4-methoxybenzyloxy)-3,5-dimethyl-1-(trimethylsilyl)hept-5-en-1-yn-4-ol

Guidance literature:: ((3R)-3-{[dihydroxy(methyl)-λ⁴-sulfanyl]oxy}but-1-yn-1-yl)(trimethyl)silane; (2E)-4-[(4-methoxybenzyl)oxy]-2-methylbut-2-enal; With palladium diacetate; triphenylphosphine; In tetrahydrofuran; at -78 ℃;

With diethylzinc; In tetrahydrofuran; at -78 - -5 ℃; optical yield given as %ee;
DOI:10.1055/s-0030-1259286

Reference yield: 70.0%

: 1283713-43-8
(3S,4S,E)-7-(4-methoxybenzyloxy)-3,5-dimethyl-1-(trimethylsilyl)hept-5-en-1-yn-4-ol

: 69739-34-0
t-butyldimethylsiyl triflate

: 1283713-72-3
((3S,4S,E)-4-tert-butyldimethylsilyloxy-7-(4-methoxybenzyloxy)-3,5-dimethylhept-5-en-1-ynyl)trimethylsilane

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at -50 ℃;
DOI:10.1055/s-0030-1259286

Reference yield:

: 1283713-43-8
(3S,4S,E)-7-(4-methoxybenzyloxy)-3,5-dimethyl-1-(trimethylsilyl)hept-5-en-1-yn-4-ol

: 1283713-73-4
C₂₃H₃₅IO₃Si

Guidance literature:: Multi-step reaction with 2 steps

1: 2,6-dimethylpyridine / dichloromethane / -50 °C

2: N-iodo-succinimide; silver nitrate / N,N-dimethyl-formamide / 5 h / 20 °C / Darkness

With 2,6-dimethylpyridine; N-iodo-succinimide; silver nitrate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-0030-1259286