(1R,2R)-2-(((S)-1-(tert-butylthio)butan-2-yl)amino)-1-(3-chlorophenyl)-2-(4-chlorophenyl)ethanol

Base Information

Chemical Name:(1R,2R)-2-(((S)-1-(tert-butylthio)butan-2-yl)amino)-1-(3-chlorophenyl)-2-(4-chlorophenyl)ethanol
CAS No.:1574555-52-4
Molecular Formula:C₂₂H₂₉Cl₂NOS
Molecular Weight:426.45
Hs Code.:

Synonyms:(1R,2R)-2-(((S)-1-(tert-butylthio)butan-2-yl)amino)-1-(3-chlorophenyl)-2-(4-chlorophenyl)ethanol

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Chemical Property of (1R,2R)-2-(((S)-1-(tert-butylthio)butan-2-yl)amino)-1-(3-chlorophenyl)-2-(4-chlorophenyl)ethanol

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Technology Process of (1R,2R)-2-(((S)-1-(tert-butylthio)butan-2-yl)amino)-1-(3-chlorophenyl)-2-(4-chlorophenyl)ethanol

There total 9 articles about (1R,2R)-2-(((S)-1-(tert-butylthio)butan-2-yl)amino)-1-(3-chlorophenyl)-2-(4-chlorophenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.1%

: 1574555-47-7
(S)-N-((1R,2R)-2-((tert-butyldimethylsilyl)oxy)-2-(3-chlorophenyl)-1-(4-chlorophenyl)ethyl)-1-(tert-butylthio)butan-2-amine

: 1574555-52-4
(1R,2R)-2-(((S)-1-(tert-butylthio)butan-2-yl)amino)-1-(3-chlorophenyl)-2-(4-chlorophenyl)ethanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm401767k

Reference yield:

: rac-(1R,2R)-2-amino-1-(3-chlorophenyl)-2-(4-chlorophenyl)ethanol hydrochloride

: 1574555-52-4
(1R,2R)-2-(((S)-1-(tert-butylthio)butan-2-yl)amino)-1-(3-chlorophenyl)-2-(4-chlorophenyl)ethanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / Inert atmosphere

1.2: Inert atmosphere; Reflux

2.1: 1H-imidazole / dichloromethane / 25 °C / Inert atmosphere

3.1: ytterbium(III) triflate / acetonitrile / 3 h / 130 °C / Microwave irradiation; Inert atmosphere

4.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 12 h / 40 °C / Inert atmosphere

5.1: indium(III) chloride / dichloromethane / 12 h / 25 °C / Inert atmosphere

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 25 °C / Inert atmosphere

With 1H-imidazole; indium(III) chloride; tetrabutyl ammonium fluoride; triphenylphosphine; sodium hydroxide; ytterbium(III) triflate; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; acetonitrile; 4.1: |Mitsunobu Displacement;
DOI:10.1021/jm401767k

Reference yield:

: C₂₀H₂₅Cl₂NO₃Si

: 1574555-52-4
(1R,2R)-2-(((S)-1-(tert-butylthio)butan-2-yl)amino)-1-(3-chlorophenyl)-2-(4-chlorophenyl)ethanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride; zinc / water / Inert atmosphere

2.1: sodium hydroxide / Inert atmosphere

2.2: Inert atmosphere; Reflux

3.1: 1H-imidazole / dichloromethane / 25 °C / Inert atmosphere

4.1: ytterbium(III) triflate / acetonitrile / 3 h / 130 °C / Microwave irradiation; Inert atmosphere

5.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 12 h / 40 °C / Inert atmosphere

6.1: indium(III) chloride / dichloromethane / 12 h / 25 °C / Inert atmosphere

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 25 °C / Inert atmosphere

With 1H-imidazole; hydrogenchloride; indium(III) chloride; tetrabutyl ammonium fluoride; triphenylphosphine; sodium hydroxide; ytterbium(III) triflate; zinc; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; water; acetonitrile; 5.1: |Mitsunobu Displacement;
DOI:10.1021/jm401767k