N-[1-[[3-(diethylamino)-3-oxopropyl]diphenylsilyl]-2-methylpropyl]-benzamide

Base Information

Chemical Name:N-[1-[[3-(diethylamino)-3-oxopropyl]diphenylsilyl]-2-methylpropyl]-benzamide
CAS No.:457097-66-4
Molecular Formula:C₃₀H₃₈N₂O₂Si
Molecular Weight:486.729
Hs Code.:

Synonyms:N-[1-[[3-(diethylamino)-3-oxopropyl]diphenylsilyl]-2-methylpropyl]-benzamide

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Chemical Property of N-[1-[[3-(diethylamino)-3-oxopropyl]diphenylsilyl]-2-methylpropyl]-benzamide

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Technology Process of N-[1-[[3-(diethylamino)-3-oxopropyl]diphenylsilyl]-2-methylpropyl]-benzamide

There total 5 articles about N-[1-[[3-(diethylamino)-3-oxopropyl]diphenylsilyl]-2-methylpropyl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 109-89-7
diethylamine

: 457097-64-2
3-[[1-(benzoylamino)-2-methylpropyl]diphenylsilyl]-propanoic acid

: 457097-66-4
N-[1-[[3-(diethylamino)-3-oxopropyl]diphenylsilyl]-2-methylpropyl]-benzamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/ol026195s

Reference yield:

: 1631-83-0
diphenylsilyl chloride

: 457097-66-4
N-[1-[[3-(diethylamino)-3-oxopropyl]diphenylsilyl]-2-methylpropyl]-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 98 percent / Pt₂[(H₂C=CHSiMe₂)O]3 / xylene / 12 h / 65 °C

2.1: lithium / tetrahydrofuran / 5 h / 20 °C

2.2: 47 percent / tetrahydrofuran / 16 h / 0 °C

3.1: 68 percent / triethylamine / CH₂Cl₂ / 16 h / 20 °C

4.1: 94 percent / conc. HCl / methanol / 1 h / Heating

5.1: 63 percent / pyridinium dichromate / dimethylformamide / 24 h / 20 °C

6.1: 67 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 24 h / 20 °C

With hydrogenchloride; dipyridinium dichromate; lithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; platinum⁽⁰⁾-1,3-divinyl-1,1,3,3-tetramethyldisiloxane complex; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; xylene;
DOI:10.1021/ol026195s

Reference yield:

: 457097-60-8
chloro[3-(methoxymethoxy)propyl]diphenylsilane

: 457097-66-4
N-[1-[[3-(diethylamino)-3-oxopropyl]diphenylsilyl]-2-methylpropyl]-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium / tetrahydrofuran / 5 h / 20 °C

1.2: 47 percent / tetrahydrofuran / 16 h / 0 °C

2.1: 68 percent / triethylamine / CH₂Cl₂ / 16 h / 20 °C

3.1: 94 percent / conc. HCl / methanol / 1 h / Heating

4.1: 63 percent / pyridinium dichromate / dimethylformamide / 24 h / 20 °C

5.1: 67 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 24 h / 20 °C

With hydrogenchloride; dipyridinium dichromate; lithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol026195s