3-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)-4-iodobenzene-1-sulfonyl fluoride

Base Information

Chemical Name:3-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)-4-iodobenzene-1-sulfonyl fluoride
CAS No.:1422570-31-7
Molecular Formula:C₁₄H₆Cl₂FIN₂O₄S
Molecular Weight:515.088
Hs Code.:

Synonyms:3-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)-4-iodobenzene-1-sulfonyl fluoride

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Chemical Property of 3-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)-4-iodobenzene-1-sulfonyl fluoride

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Technology Process of 3-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)-4-iodobenzene-1-sulfonyl fluoride

There total 9 articles about 3-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)-4-iodobenzene-1-sulfonyl fluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1422570-77-1
3-(5-(3,5-dichloro-4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)-4-iodobenzene-1-sulfonyl fluoride

: 1422570-31-7
3-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)-4-iodobenzene-1-sulfonyl fluoride

Guidance literature:: With lithium iodide; In ethyl acetate; at 110 ℃; for 5h; Inert atmosphere; Sealed tube;
DOI:10.1021/ja311729d

Reference yield:

: 850453-87-1
5-(chlorosulfonyl)-2-iodobenzoic acid

: 1422570-31-7
3-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)-4-iodobenzene-1-sulfonyl fluoride

Guidance literature:: Multi-step reaction with 5 steps

1: potassium hydrogen bifluoride / 1,4-dioxane; water / 0.5 h / 20 °C / Inert atmosphere

2: thionyl chloride / 2 h / 75 °C / Inert atmosphere

3: triethylamine / dichloromethane; dimethyl sulfoxide / 0.33 h / 20 °C / Inert atmosphere

4: p-toluenesulfonyl chloride; dmap / dichloromethane / 0.17 h / 20 °C / Inert atmosphere

5: lithium iodide / ethyl acetate / 5 h / 110 °C / Inert atmosphere; Sealed tube

With dmap; thionyl chloride; potassium hydrogen bifluoride; triethylamine; p-toluenesulfonyl chloride; lithium iodide; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/ja311729d

Reference yield:

: 1422570-55-5
5-(fluorosulfonyl)-2-iodobenzoic acid

: 1422570-31-7
3-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)-4-iodobenzene-1-sulfonyl fluoride

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 2 h / 75 °C / Inert atmosphere

2: triethylamine / dichloromethane; dimethyl sulfoxide / 0.33 h / 20 °C / Inert atmosphere

3: p-toluenesulfonyl chloride; dmap / dichloromethane / 0.17 h / 20 °C / Inert atmosphere

4: lithium iodide / ethyl acetate / 5 h / 110 °C / Inert atmosphere; Sealed tube

With dmap; thionyl chloride; triethylamine; p-toluenesulfonyl chloride; lithium iodide; In dichloromethane; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/ja311729d