diethyl (2S)-2-[(2-benzyl-3-{[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]amino}-3-oxopropanoyl)amino]pentanedioate

Base Information

Chemical Name:diethyl (2S)-2-[(2-benzyl-3-{[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]amino}-3-oxopropanoyl)amino]pentanedioate
CAS No.:852233-56-8
Molecular Formula:C₃₅H₃₆N₄O₈
Molecular Weight:640.693
Hs Code.:

Synonyms:diethyl (2S)-2-[(2-benzyl-3-{[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]amino}-3-oxopropanoyl)amino]pentanedioate

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Chemical Property of diethyl (2S)-2-[(2-benzyl-3-{[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]amino}-3-oxopropanoyl)amino]pentanedioate

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Technology Process of diethyl (2S)-2-[(2-benzyl-3-{[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]amino}-3-oxopropanoyl)amino]pentanedioate

There total 9 articles about diethyl (2S)-2-[(2-benzyl-3-{[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]amino}-3-oxopropanoyl)amino]pentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 852233-57-9
2-benzyl-N-[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]-3-oxo-β-alanine

: L-glutamic acid ethyl ester p-toluenesulphonate

: 852233-56-8
diethyl (2S)-2-[(2-benzyl-3-{[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]amino}-3-oxopropanoyl)amino]pentanedioate

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In DMF (N,N-dimethyl-formamide); for 4h;

Reference yield:

: 607367-17-9
2-benzyl-malonic acid benzyl ester methyl ester

: 852233-56-8
diethyl (2S)-2-[(2-benzyl-3-{[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]amino}-3-oxopropanoyl)amino]pentanedioate

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / H₂ / Pd/C / tetrahydrofuran / 20 °C

2: 33 percent / N-methylmorpholine; 1-hydroxybezotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / dimethylformamide / pH 7

3: 89 percent / aq. NaOH / ethanol / 20 °C

4: 1-hydroxybenzotriazole; N-methylmorpholine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / dimethylformamide / pH 7

With 4-methyl-morpholine; sodium hydroxide; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm048984g

Reference yield:

: 852233-49-9
4-[(7-nitro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)methyl]benzonitrile

: 852233-56-8
diethyl (2S)-2-[(2-benzyl-3-{[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]amino}-3-oxopropanoyl)amino]pentanedioate

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / H₂ / Pd/C / dimethylformamide / 20 °C

2: 33 percent / N-methylmorpholine; 1-hydroxybezotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / dimethylformamide / pH 7

3: 89 percent / aq. NaOH / ethanol / 20 °C

4: 1-hydroxybenzotriazole; N-methylmorpholine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / dimethylformamide / pH 7

With 4-methyl-morpholine; sodium hydroxide; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm048984g