2-methoxy-4-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzamido)benzoic acid hydrochloride

Base Information

Chemical Name:2-methoxy-4-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzamido)benzoic acid hydrochloride
CAS No.:1415694-78-8
Molecular Formula:C₃₁H₂₉N₇O₄*ClH
Molecular Weight:600.077
Hs Code.:

Synonyms:2-methoxy-4-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzamido)benzoic acid hydrochloride

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Chemical Property of 2-methoxy-4-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzamido)benzoic acid hydrochloride

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Technology Process of 2-methoxy-4-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzamido)benzoic acid hydrochloride

There total 11 articles about 2-methoxy-4-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzamido)benzoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1415695-23-6
Methyl 2-methoxy-4-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]-triazolo[1,5-a]pyridin-6-yl)benzamido)benzoate

: 1415694-78-8
2-methoxy-4-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzamido)benzoic acid hydrochloride

Guidance literature:: Methyl 2-methoxy-4-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]-triazolo[1,5-a]pyridin-6-yl)benzamido)benzoate; With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 16h;

With hydrogenchloride; In tetrahydrofuran; water; pH=3;

With hydrogenchloride; In water; pH=1;

Reference yield:

: 27492-84-8
Methyl 4-amino-2-methoxybenzoate

: 1415694-78-8
2-methoxy-4-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzamido)benzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / N,N-dimethyl-formamide / 36 h / 20 °C

2.1: cesium fluoride; sodium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 16 h / 20 - 96 °C / Inert atmosphere

3.1: sodium hydroxide / water; tetrahydrofuran; methanol / 16 h / 20 °C

3.2: pH 3

With sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; cesium fluoride; sodium hydroxide; XPhos; dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 269409-73-6
3-carboxyphenylboronic acid pinacol ester

: 1415694-78-8
2-methoxy-4-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzamido)benzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / N,N-dimethyl-formamide / 36 h / 20 °C

2.1: cesium fluoride; sodium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 16 h / 20 - 96 °C / Inert atmosphere

3.1: sodium hydroxide / water; tetrahydrofuran; methanol / 16 h / 20 °C

3.2: pH 3

With sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; cesium fluoride; sodium hydroxide; XPhos; dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;