Methyl 2-methoxy-4-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]-triazolo[1,5-a]pyridin-6-yl)benzamido)benzoate

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Chemical Name:Methyl 2-methoxy-4-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]-triazolo[1,5-a]pyridin-6-yl)benzamido)benzoate
CAS No.:1415695-23-6
Molecular Formula:C₃₂H₃₁N₇O₄
Molecular Weight:577.643
Hs Code.:

Synonyms:Methyl 2-methoxy-4-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]-triazolo[1,5-a]pyridin-6-yl)benzamido)benzoate

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Chemical Property of Methyl 2-methoxy-4-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]-triazolo[1,5-a]pyridin-6-yl)benzamido)benzoate

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Technology Process of Methyl 2-methoxy-4-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]-triazolo[1,5-a]pyridin-6-yl)benzamido)benzoate

There total 10 articles about Methyl 2-methoxy-4-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]-triazolo[1,5-a]pyridin-6-yl)benzamido)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1401461-98-0
methyl 2-methoxy-4-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamido)benzoate

: 1415695-22-5
6-chloro-N-(6-(2-methylpyrrolidin-1-yl)pyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyridin-8-amine

: 1415695-23-6
Methyl 2-methoxy-4-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]-triazolo[1,5-a]pyridin-6-yl)benzamido)benzoate

Guidance literature:: With sodium carbonate; cesium fluoride; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; at 20 - 96 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1072-98-6
5-chloro-2-pyridylamine

: 1415695-23-6
Methyl 2-methoxy-4-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]-triazolo[1,5-a]pyridin-6-yl)benzamido)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: iodine; silver sulfate / 20 °C

2.1: isopropyl alcohol / 5 h / 20 - 100 °C

2.2: 16 h / 50 - 60 °C

3.1: trifluoroacetic anhydride / tetrahydrofuran / 16 h / 0 - 20 °C

4.1: caesium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / xylene / 16.16 h / 20 - 140 °C / Inert atmosphere

5.1: cesium fluoride; sodium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 16 h / 20 - 96 °C / Inert atmosphere

With iodine; sodium carbonate; caesium carbonate; silver sulfate; cesium fluoride; trifluoroacetic anhydride; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; isopropyl alcohol; xylene;

Reference yield:

: 27492-84-8
Methyl 4-amino-2-methoxybenzoate

: 1415695-23-6
Methyl 2-methoxy-4-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]-triazolo[1,5-a]pyridin-6-yl)benzamido)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / N,N-dimethyl-formamide / 36 h / 20 °C

2: cesium fluoride; sodium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 16 h / 20 - 96 °C / Inert atmosphere

With sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; cesium fluoride; XPhos; dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; N,N-dimethyl-formamide;