trans-methyl-{4-[5-(methyl-propyl-amino)-pent-1-ynyl]cyclohexyl}carbamic acid 4-chlorophenyl ester

Base Information

Chemical Name:trans-methyl-{4-[5-(methyl-propyl-amino)-pent-1-ynyl]cyclohexyl}carbamic acid 4-chlorophenyl ester
CAS No.:400897-10-1
Molecular Formula:C₂₃H₃₃ClN₂O₂
Molecular Weight:404.98
Hs Code.:

Synonyms:trans-methyl-{4-[5-(methyl-propyl-amino)-pent-1-ynyl]cyclohexyl}carbamic acid 4-chlorophenyl ester

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Chemical Property of trans-methyl-{4-[5-(methyl-propyl-amino)-pent-1-ynyl]cyclohexyl}carbamic acid 4-chlorophenyl ester

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Technology Process of trans-methyl-{4-[5-(methyl-propyl-amino)-pent-1-ynyl]cyclohexyl}carbamic acid 4-chlorophenyl ester

There total 5 articles about trans-methyl-{4-[5-(methyl-propyl-amino)-pent-1-ynyl]cyclohexyl}carbamic acid 4-chlorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 627-35-0
methyl-n-propylamine

: 400899-69-6
C₂₀H₂₆ClNO₅S

: 400897-10-1
trans-methyl-{4-[5-(methyl-propyl-amino)-pent-1-ynyl]cyclohexyl}carbamic acid 4-chlorophenyl ester

Guidance literature:: With sodium iodide; In methanol; at 60 ℃; Inert atmosphere;
DOI:10.1021/jm300256z

Reference yield:

: 400899-68-5
C₂HF₃O₂*C₁₃H₂₃NO₃S

: 400897-10-1
trans-methyl-{4-[5-(methyl-propyl-amino)-pent-1-ynyl]cyclohexyl}carbamic acid 4-chlorophenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.75 h / 0 °C / Inert atmosphere

2: sodium iodide / methanol / 60 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; sodium iodide; In methanol; dichloromethane;
DOI:10.1021/jm300256z

Reference yield:

: 400899-56-1
trans-[4-(4-hydroxy-but-1-ynyl)cyclohexyl]methylcarbamic acid tert-butyl ester

: 400897-10-1
trans-methyl-{4-[5-(methyl-propyl-amino)-pent-1-ynyl]cyclohexyl}carbamic acid 4-chlorophenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine; dmap / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2: dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.75 h / 0 °C / Inert atmosphere

4: sodium iodide / methanol / 60 °C / Inert atmosphere

With pyridine; dmap; N-ethyl-N,N-diisopropylamine; sodium iodide; In methanol; dichloromethane;
DOI:10.1021/jm300256z