trans-[4-(4-hydroxy-but-1-ynyl)cyclohexyl]methylcarbamic acid tert-butyl ester

Base Information

• Chemical Name: trans-[4-(4-hydroxy-but-1-ynyl)cyclohexyl]methylcarbamic acid tert-butyl ester
• CAS No.: 400899-56-1
• Molecular Formula: C₁₆H₂₇NO₃
• Molecular Weight: 281.395
• Mol file: 400899-56-1.mol

Synonyms:trans-[4-(4-hydroxy-but-1-ynyl)cyclohexyl]methylcarbamic acid tert-butyl ester

Chemical Property of trans-[4-(4-hydroxy-but-1-ynyl)cyclohexyl]methylcarbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of trans-[4-(4-hydroxy-but-1-ynyl)cyclohexyl]methylcarbamic acid tert-butyl ester

There total 1 articles about trans-[4-(4-hydroxy-but-1-ynyl)cyclohexyl]methylcarbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

C22H37NO4 (400898-97-7) → trans-[4-(4-hydroxy-but-1-ynyl)cyclohexyl]methylcarbamic acid tert-butyl ester (400899-56-1)

Guidance literature:

With pyridinium p-toluenesulfonate; In methanol; at 55 ℃; for 1.5h; Inert atmosphere;

DOI:10.1021/jm300256z

Reference yield: 100.0%

trans-[4-(4-hydroxy-but-1-ynyl)cyclohexyl]methylcarbamic acid tert-butyl ester (400899-56-1) + methanesulfonyl chloride (124-63-0) → trans-methanesulfonic acid 4-[4-(N-(tert-butoxycarbonyl)-N-methylamino)cyclohexyl]but-3-ynyl ester (400899-57-2)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/jm300256z

Reference yield:

trans-[4-(4-hydroxy-but-1-ynyl)cyclohexyl]methylcarbamic acid tert-butyl ester (400899-56-1) → C2HF3O2*C13H23NO3S (400899-68-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; dmap / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2: dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With pyridine; dmap; In dichloromethane;

DOI:10.1021/jm300256z

upstream raw materials:

C₂₂H₃₇NO₄

Downstream raw materials:

C₂HF₃O₂*C₁₃H₂₃NO₃S

C₂₀H₂₆ClNO₅S

trans-(4-{5-[ethyl-(2-hydroxyethyl)amino]pent-1-ynyl}-cyclohexyl)methylcarbamic acid 4-chlorophenyl ester

trans-methyl-{4-[5-(methyl-propyl-amino)-pent-1-ynyl]cyclohexyl}carbamic acid 4-chlorophenyl ester