5-(((3S)-4-(4-(R)-(S-cyclopropylsulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

Base Information

Chemical Name:5-(((3S)-4-(4-(R)-(S-cyclopropylsulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine
CAS No.:1572927-61-7
Molecular Formula:C₂₁H₂₅N₅O₃S₂
Molecular Weight:459.593
Hs Code.:

Synonyms:5-(((3S)-4-(4-(R)-(S-cyclopropylsulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

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Chemical Property of 5-(((3S)-4-(4-(R)-(S-cyclopropylsulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

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Technology Process of 5-(((3S)-4-(4-(R)-(S-cyclopropylsulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

There total 14 articles about 5-(((3S)-4-(4-(R)-(S-cyclopropylsulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1572928-26-7
tert-butyl (5-(((3S )-4-(4-(cyclopropylsulfinyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)-sulfonyl)-2-pyridinyl)carbamate

: 1572927-60-6
5-(((3S)-4-(4-(S)-(S-cyclopropylsulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

: 1572927-61-7
5-(((3S)-4-(4-(R)-(S-cyclopropylsulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

Guidance literature:: tert-butyl (5-(((3S )-4-(4-(cyclopropylsulfinyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)-sulfonyl)-2-pyridinyl)carbamate; With sodium azide; In chloroform; at 20 ℃;

With sulfuric acid; In chloroform; at 0 - 20 ℃; for 6h;

Reference yield:

: 1572928-23-4
(2S)-4-benzyl-1-(4-(cyclopropylsulfanyl)phenyl)-2-(1-propyn-1-yl)piperazine

: 1572927-60-6
5-(((3S)-4-(4-(S)-(S-cyclopropylsulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

: 1572927-61-7
5-(((3S)-4-(4-(R)-(S-cyclopropylsulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; carbonochloridic acid 1-chloro-ethyl ester / dichloromethane / 12 h / 0 - 20 °C

1.2: 2 h / 80 °C

2.1: pyridine / dichloromethane / 1 h / 20 °C / Inert atmosphere

3.1: dihydrogen peroxide; acetic acid / water / 1.5 h / 0 - 20 °C

4.1: sodium azide / chloroform / 20 °C

4.2: 6 h / 0 - 20 °C

With pyridine; sodium azide; carbonochloridic acid 1-chloro-ethyl ester; dihydrogen peroxide; potassium carbonate; acetic acid; In dichloromethane; chloroform; water;

Reference yield:

: 1572928-24-5
(2S)-1-(4-(cyclopropylsulfanyl)phenyl)-2-(1-propyn-1-yl)piperazine

: 1572927-60-6
5-(((3S)-4-(4-(S)-(S-cyclopropylsulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

: 1572927-61-7
5-(((3S)-4-(4-(R)-(S-cyclopropylsulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / dichloromethane / 1 h / 20 °C / Inert atmosphere

2.1: dihydrogen peroxide; acetic acid / water / 1.5 h / 0 - 20 °C

3.1: sodium azide / chloroform / 20 °C

3.2: 6 h / 0 - 20 °C

With pyridine; sodium azide; dihydrogen peroxide; acetic acid; In dichloromethane; chloroform; water;