2,2,5-trimethyl-3-(1'-p-((S)-(-)-2''-(t-butyl-oxy-carbonylamide)-3''-(p-oxyphenyl)-1'',1''-diphenylpropan-1''-ol)benzylethoxy)-4-phenyl-3-azahexane

Base Information

Chemical Name:2,2,5-trimethyl-3-(1'-p-((S)-(-)-2''-(t-butyl-oxy-carbonylamide)-3''-(p-oxyphenyl)-1'',1''-diphenylpropan-1''-ol)benzylethoxy)-4-phenyl-3-azahexane
CAS No.:496816-90-1
Molecular Formula:C₄₉H₆₀N₂O₅
Molecular Weight:757.026
Hs Code.:

Synonyms:2,2,5-trimethyl-3-(1'-p-((S)-(-)-2''-(t-butyl-oxy-carbonylamide)-3''-(p-oxyphenyl)-1'',1''-diphenylpropan-1''-ol)benzylethoxy)-4-phenyl-3-azahexane

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Chemical Property of 2,2,5-trimethyl-3-(1'-p-((S)-(-)-2''-(t-butyl-oxy-carbonylamide)-3''-(p-oxyphenyl)-1'',1''-diphenylpropan-1''-ol)benzylethoxy)-4-phenyl-3-azahexane

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Technology Process of 2,2,5-trimethyl-3-(1'-p-((S)-(-)-2''-(t-butyl-oxy-carbonylamide)-3''-(p-oxyphenyl)-1'',1''-diphenylpropan-1''-ol)benzylethoxy)-4-phenyl-3-azahexane

There total 3 articles about 2,2,5-trimethyl-3-(1'-p-((S)-(-)-2''-(t-butyl-oxy-carbonylamide)-3''-(p-oxyphenyl)-1'',1''-diphenylpropan-1''-ol)benzylethoxy)-4-phenyl-3-azahexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.2%

: 24424-99-5
di-tert-butyl dicarbonate

: 2,2,5-trimethyl-3-(1'-(p-((S)-(-)-2''-amino-3''-p-oxyphenyl)-1'',1''-diphenylpropan-1''-ol)benzylethoxy)-4-phenyl-3-azahexane

: 496816-90-1
2,2,5-trimethyl-3-(1'-p-((S)-(-)-2''-(t-butyl-oxy-carbonylamide)-3''-(p-oxyphenyl)-1'',1''-diphenylpropan-1''-ol)benzylethoxy)-4-phenyl-3-azahexane

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/ja028392s

Reference yield:

: 104942-25-8
(S)-(-)-2-amino-3-(p-hydroxyphenyl)-1,1-diphenylpropan-1-ol

: 496816-90-1
2,2,5-trimethyl-3-(1'-p-((S)-(-)-2''-(t-butyl-oxy-carbonylamide)-3''-(p-oxyphenyl)-1'',1''-diphenylpropan-1''-ol)benzylethoxy)-4-phenyl-3-azahexane

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH; 18-crown-6 / tetrahydrofuran / 0.25 h

1.2: 86.2 percent / tetrahydrofuran / 16 h / Heating

2.1: 56.2 percent / Et₃N / tetrahydrofuran / 2 h / 20 °C

With 18-crown-6 ether; sodium hydride; triethylamine; In tetrahydrofuran;
DOI:10.1021/ja028392s

Reference yield:

: 227000-85-3
N-tert-butyl-O-[1-(4-chloromethyl-phenyl)-ethyl]-N-(2-methyl-1-phenyl-propyl)-hydroxylamine

: 496816-90-1
2,2,5-trimethyl-3-(1'-p-((S)-(-)-2''-(t-butyl-oxy-carbonylamide)-3''-(p-oxyphenyl)-1'',1''-diphenylpropan-1''-ol)benzylethoxy)-4-phenyl-3-azahexane

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH; 18-crown-6 / tetrahydrofuran / 0.25 h

1.2: 86.2 percent / tetrahydrofuran / 16 h / Heating

2.1: 56.2 percent / Et₃N / tetrahydrofuran / 2 h / 20 °C

With 18-crown-6 ether; sodium hydride; triethylamine; In tetrahydrofuran;
DOI:10.1021/ja028392s