ethyl 5-[(1E)-3-({2-[2,4-dichloro(methyl)-3-({[2-methyl-4-(4-morpholinyl)-8-quinolinyl]oxy}methyl)anilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-2-pyridinecarboxylate

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Chemical Name:ethyl 5-[(1E)-3-({2-[2,4-dichloro(methyl)-3-({[2-methyl-4-(4-morpholinyl)-8-quinolinyl]oxy}methyl)anilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-2-pyridinecarboxylate
CAS No.:179624-53-4
Molecular Formula:C₃₅H₃₅Cl₂N₅O₆
Molecular Weight:692.599
Hs Code.:

ethyl 5-[(1E)-3-({2-[2,4-dichloro(methyl)-3-({[2-methyl-4-(4-morpholinyl)-8-quinolinyl]oxy}methyl)anilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-2-pyridinecarboxylate

Synonyms:ethyl 5-[(1E)-3-({2-[2,4-dichloro(methyl)-3-({[2-methyl-4-(4-morpholinyl)-8-quinolinyl]oxy}methyl)anilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-2-pyridinecarboxylate

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Chemical Property of ethyl 5-[(1E)-3-({2-[2,4-dichloro(methyl)-3-({[2-methyl-4-(4-morpholinyl)-8-quinolinyl]oxy}methyl)anilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-2-pyridinecarboxylate

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Technology Process of ethyl 5-[(1E)-3-({2-[2,4-dichloro(methyl)-3-({[2-methyl-4-(4-morpholinyl)-8-quinolinyl]oxy}methyl)anilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-2-pyridinecarboxylate

There total 7 articles about ethyl 5-[(1E)-3-({2-[2,4-dichloro(methyl)-3-({[2-methyl-4-(4-morpholinyl)-8-quinolinyl]oxy}methyl)anilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-2-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.8%

: 160648-19-1
(E)-3-[6-(ethoxycarbonyl)pyridin-3-yl]acrylic acid

: 179626-19-8
2-amino-N-[2,4-dichloro-3-({[2-methyl-4-(4-morpholinyl)-8-quinolinyl]oxy}methyl)phenyl]-N-methylacetamide

: 179624-53-4
ethyl 5-[(1E)-3-({2-[2,4-dichloro(methyl)-3-({[2-methyl-4-(4-morpholinyl)-8-quinolinyl]oxy}methyl)anilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-2-pyridinecarboxylate

Guidance literature:: With 1-(3-dimethylaminopropyl)-3-ethoxycarbodiimide hydrochloride; benzotriazol-1-ol; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1021/jm030326t

Reference yield:

: 28507-46-2
4-chloro-8-hydroxy-2-methylquinoline

: 179624-53-4
ethyl 5-[(1E)-3-({2-[2,4-dichloro(methyl)-3-({[2-methyl-4-(4-morpholinyl)-8-quinolinyl]oxy}methyl)anilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-2-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 91.1 percent / phenol / 10 h / 125 °C

2: 97 percent / K₂CO₃ / dimethylformamide / 24 h / 20 °C

3: 83.7 percent / hydrazine monohydrate / ethanol / 1 h / Heating

4: 84.8 percent / 1-ethoxy-3-[3-(dimethylamino)propyl]carbodiimide*HCl; 1-hydroxybenzotriazole / dimethylformamide / 3 h / 20 °C

With 1-(3-dimethylaminopropyl)-3-ethoxycarbodiimide hydrochloride; potassium carbonate; benzotriazol-1-ol; hydrazine hydrate; phenol; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm030326t

Reference yield:

: 167837-48-1
N-(2,4-dichloro-3-(hydroxymethyl)phenyl)-2-(1,3-dioxoisoindolin-2-yl)-N-methylacetamide

: 179624-53-4
ethyl 5-[(1E)-3-({2-[2,4-dichloro(methyl)-3-({[2-methyl-4-(4-morpholinyl)-8-quinolinyl]oxy}methyl)anilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-2-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 0.5 h / cooling

2: 97 percent / K₂CO₃ / dimethylformamide / 24 h / 20 °C

3: 83.7 percent / hydrazine monohydrate / ethanol / 1 h / Heating

4: 84.8 percent / 1-ethoxy-3-[3-(dimethylamino)propyl]carbodiimide*HCl; 1-hydroxybenzotriazole / dimethylformamide / 3 h / 20 °C

With 1-(3-dimethylaminopropyl)-3-ethoxycarbodiimide hydrochloride; potassium carbonate; benzotriazol-1-ol; hydrazine hydrate; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030326t