N-(2,4-dichloro-3-(hydroxymethyl)phenyl)-2-(1,3-dioxoisoindolin-2-yl)-N-methylacetamide

Base Information

Chemical Name:N-(2,4-dichloro-3-(hydroxymethyl)phenyl)-2-(1,3-dioxoisoindolin-2-yl)-N-methylacetamide
CAS No.:167837-48-1
Molecular Formula:C₁₈H₁₄Cl₂N₂O₄
Molecular Weight:393.226
Hs Code.:

Synonyms:N-(2,4-dichloro-3-(hydroxymethyl)phenyl)-2-(1,3-dioxoisoindolin-2-yl)-N-methylacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2,4-dichloro-3-(hydroxymethyl)phenyl)-2-(1,3-dioxoisoindolin-2-yl)-N-methylacetamide

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Technology Process of N-(2,4-dichloro-3-(hydroxymethyl)phenyl)-2-(1,3-dioxoisoindolin-2-yl)-N-methylacetamide

There total 10 articles about N-(2,4-dichloro-3-(hydroxymethyl)phenyl)-2-(1,3-dioxoisoindolin-2-yl)-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 167837-47-0
N-(3-((tert-butyldiphenylsilyloxy)methyl)-2,4-dichlorophenyl)-2-(1,3-dioxoisoindolin-2-yl)-N-methylacetamide

: 167837-48-1
N-(2,4-dichloro-3-(hydroxymethyl)phenyl)-2-(1,3-dioxoisoindolin-2-yl)-N-methylacetamide

Guidance literature:: With tetra-n-butylammoniumfluoride trihydrate; In water; at 25 ℃; for 3h;
DOI:10.1016/j.ejmech.2020.112948

Reference yield:

: 6780-38-7
N-phthaloylglycine chloride

: 167837-48-1
N-(2,4-dichloro-3-(hydroxymethyl)phenyl)-2-(1,3-dioxoisoindolin-2-yl)-N-methylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 89.3 percent / Et₃N / CH₂Cl₂ / 1.5 h / 0 - 20 °C

2: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 2 h

3: TBAF / tetrahydrofuran / 1 h / Ambient temperature

With tetrabutyl ammonium fluoride; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm980300f

Reference yield:

: 167837-45-8
3-amino-1-(tert-butyldiphenylsilyloxymethyl)-2,6-dichlorobenzene

: 167837-48-1
N-(2,4-dichloro-3-(hydroxymethyl)phenyl)-2-(1,3-dioxoisoindolin-2-yl)-N-methylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 89.3 percent / Et₃N / CH₂Cl₂ / 1.5 h / 0 - 20 °C

2: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 2 h

3: TBAF / tetrahydrofuran / 1 h / Ambient temperature

With tetrabutyl ammonium fluoride; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm980300f