2-amino-N-[2,4-dichloro-3-({[2-methyl-4-(4-morpholinyl)-8-quinolinyl]oxy}methyl)phenyl]-N-methylacetamide

Base Information

Chemical Name:2-amino-N-[2,4-dichloro-3-({[2-methyl-4-(4-morpholinyl)-8-quinolinyl]oxy}methyl)phenyl]-N-methylacetamide
CAS No.:179626-19-8
Molecular Formula:C₂₄H₂₆Cl₂N₄O₃
Molecular Weight:489.401
Hs Code.:

Synonyms:2-amino-N-[2,4-dichloro-3-({[2-methyl-4-(4-morpholinyl)-8-quinolinyl]oxy}methyl)phenyl]-N-methylacetamide

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Chemical Property of 2-amino-N-[2,4-dichloro-3-({[2-methyl-4-(4-morpholinyl)-8-quinolinyl]oxy}methyl)phenyl]-N-methylacetamide

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Technology Process of 2-amino-N-[2,4-dichloro-3-({[2-methyl-4-(4-morpholinyl)-8-quinolinyl]oxy}methyl)phenyl]-N-methylacetamide

There total 5 articles about 2-amino-N-[2,4-dichloro-3-({[2-methyl-4-(4-morpholinyl)-8-quinolinyl]oxy}methyl)phenyl]-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.7%

: 179626-16-5
N-[2,4-dichloro-3-({[2-methyl-4-(4-morpholinyl)-8-quinolinyl]oxy}methyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-methylacetamide

: 179626-19-8
2-amino-N-[2,4-dichloro-3-({[2-methyl-4-(4-morpholinyl)-8-quinolinyl]oxy}methyl)phenyl]-N-methylacetamide

Guidance literature:: With hydrazine hydrate; In ethanol; for 1h; Heating;
DOI:10.1021/jm030326t

Reference yield:

: 28507-46-2
4-chloro-8-hydroxy-2-methylquinoline

: 179626-19-8
2-amino-N-[2,4-dichloro-3-({[2-methyl-4-(4-morpholinyl)-8-quinolinyl]oxy}methyl)phenyl]-N-methylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 91.1 percent / phenol / 10 h / 125 °C

2: 97 percent / K₂CO₃ / dimethylformamide / 24 h / 20 °C

3: 83.7 percent / hydrazine monohydrate / ethanol / 1 h / Heating

With potassium carbonate; hydrazine hydrate; phenol; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm030326t

Reference yield:

: 167837-48-1
N-(2,4-dichloro-3-(hydroxymethyl)phenyl)-2-(1,3-dioxoisoindolin-2-yl)-N-methylacetamide

: 179626-19-8
2-amino-N-[2,4-dichloro-3-({[2-methyl-4-(4-morpholinyl)-8-quinolinyl]oxy}methyl)phenyl]-N-methylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 0.5 h / cooling

2: 97 percent / K₂CO₃ / dimethylformamide / 24 h / 20 °C

3: 83.7 percent / hydrazine monohydrate / ethanol / 1 h / Heating

With potassium carbonate; hydrazine hydrate; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030326t