2-(4-bromophenylcarbamoyl)-4-chlorophenyl 4-(trifluoromethyl)benzoate

Base Information

• Chemical Name: 2-(4-bromophenylcarbamoyl)-4-chlorophenyl 4-(trifluoromethyl)benzoate
• CAS No.: 1403607-27-1
• Molecular Formula: C₂₁H₁₂BrClF₃NO₃
• Molecular Weight: 498.683
• Mol file: 1403607-27-1.mol

Synonyms:2-(4-bromophenylcarbamoyl)-4-chlorophenyl 4-(trifluoromethyl)benzoate

Chemical Property of 2-(4-bromophenylcarbamoyl)-4-chlorophenyl 4-(trifluoromethyl)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-bromophenylcarbamoyl)-4-chlorophenyl 4-(trifluoromethyl)benzoate

There total 2 articles about 2-(4-bromophenylcarbamoyl)-4-chlorophenyl 4-(trifluoromethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

4-trifluoromethylbenzoic acid (455-24-3) + N-(4-bromophenyl)-5-chloro-2-hydroxyl benzamide (2627-75-0) → 2-(4-bromophenylcarbamoyl)-4-chlorophenyl 4-(trifluoromethyl)benzoate (1403607-27-1)

Guidance literature:

With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at -20 - 4 ℃; for 52h;

DOI:10.3390/molecules17089426

Reference yield:

5-chloro-2-hydroxybenzoic acid (321-14-2) + 4-bromo-aniline (106-40-1) → 2-(4-bromophenylcarbamoyl)-4-chlorophenyl 4-(trifluoromethyl)benzoate (1403607-27-1)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorus trichloride / chlorobenzene / 0.33 h / Reflux; Microwave irradiation

2: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 52 h / -20 - 4 °C

With dicyclohexyl-carbodiimide; phosphorus trichloride; In N,N-dimethyl-formamide; chlorobenzene;

DOI:10.3390/molecules17089426

upstream raw materials:

5-chloro-2-hydroxybenzoic acid

4-bromo-aniline

4-trifluoromethylbenzoic acid

N-(4-bromophenyl)-5-chloro-2-hydroxyl benzamide